PMID- 16682515
OWN - NLM
STAT- MEDLINE
DCOM- 20060626
LR  - 20061115
IS  - 0091-7370 (Print)
IS  - 0091-7370 (Linking)
VI  - 36
IP  - 2
DP  - 2006 Spring
TI  - Murine cytomegalovirus infection markedly reduces serum MCP-1 levels in MCP-1 
      transgenic mice.
PG  - 179-84
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a pro-inflammatory chemokine 
      believed to play a major role in atherogenesis. Injured endothelial cells express 
      MCP-1, which attracts monocytes to the blood vessel wall and leads to the 
      formation of atheromas. Cytomegalovirus infection may also play a role in 
      atherogenesis and accelerates inflammation in tissues that overexpress MCP-1. To 
      examine the relationship of cytomegalovirus infection and MCP-1, we infected 
      MCP-1 transgenic mice with murine cytomegalovirus (MCMV) and collected serum 6 
      days post-infection to evaluate TH1-related cytokine levels by ELISA. Serum 
      levels of IL-10, IL-12 and IFN-gamma were increased in MCP-1 transgenic mice on 
      day 6 following MCMV infection, while levels of IL-1beta and TNF-alpha were 
      undetectable. However, MCP-1 serum levels were reduced >50% in MCP-1 transgenic 
      mice following MCMV infection compared to uninfected transgenic mice. This effect 
      was not as dramatic when an M33 null MCMV was administered to MCP-1 transgenic 
      mice. The mechanism by which MCMV lowers serum MCP-1 levels is unknown, but this 
      effect may enhance the survival of the virus and thus allow CMV to contribute to 
      the chronic inflammation of atherogenesis.
FAU - Froberg, M Kent
AU  - Froberg MK
AD  - Department of Pathology, School of Medicine, University of Minnesota Duluth, 1035 
      University Drive, Duluth, MN 58812, USA. kfroberg@d.umn.edu
FAU - Dannen, Devon
AU  - Dannen D
FAU - Adams, Alice
AU  - Adams A
FAU - Parker-Thornburg, Jan
AU  - Parker-Thornburg J
FAU - Kolattukudy, Pappachan
AU  - Kolattukudy P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/blood/*virology
MH  - Chemokine CCL2/*blood/physiology
MH  - Cytokines/*blood
MH  - Female
MH  - Herpesviridae Infections/*blood
MH  - Inflammation/blood/virology
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Muromegalovirus/*pathogenicity
EDAT- 2006/05/10 09:00
MHDA- 2006/06/27 09:00
CRDT- 2006/05/10 09:00
PHST- 2006/05/10 09:00 [pubmed]
PHST- 2006/06/27 09:00 [medline]
PHST- 2006/05/10 09:00 [entrez]
AID - 36/2/179 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2006 Spring;36(2):179-84.