PMID- 16686376
OWN - NLM
STAT- MEDLINE
DCOM- 20061129
LR  - 20060511
IS  - 1050-6586 (Print)
IS  - 1050-6586 (Linking)
VI  - 20
IP  - 2
DP  - 2006 Mar-Apr
TI  - Th2 immunological inflammation in allergic fungal sinusitis, nonallergic 
      eosinophilic fungal sinusitis, and chronic rhinosinusitis.
PG  - 145-9
AB  - BACKGROUND: Noninvasive fungal sinusitis is a heterogenous group of conditions 
      including allergic fungal sinusitis (AFS) and nonallergic eosinophilic fungal 
      sinusitis (NEFS). Th2-mediated cascades have been postulated to be the major 
      inflammatory response in patients with AFS although other mechanisms also may be 
      involved. The detailed mucosal Th2 cytological status of NEFS still has not been 
      studied in great depth. METHODS: Using a meticulous patient selection algorithm 
      over a 2-year period, infundibular mucosal tissue from patients with AFS, NEFS, 
      chronic rhinosinusitis (CRS), and normal controls was studied (n = 59). 
      Immunohistochemistry for mast cells, eosinophils, and immunoglobulin E (IgE) 
      cells was performed and cell counts per unit area were measured. RESULTS: Mast 
      cell, eosinophil, and IgE+ cell numbers were significantly raised in patients 
      with AFS, NEFS, and CRS when compared with controls. There was no significant 
      difference between cell numbers in patients with AFS and NEFS. CONCLUSION: 
      Patients with AFS exhibit a classic Th2 inflammatory response in nasal mucosal 
      tissue with NEFS and CRS patients showing evidence of a similar Th2 cascade, 
      including the presence of IgE+ cells.
FAU - Carney, A Simon
AU  - Carney AS
AD  - Department of Otolaryngology-Head and Neck Surgery, Flinders Medical Center, 
      Bedford Park, South Australia 5042, Australia. scarney@ent-surgery.com
FAU - Tan, Lor-Wai
AU  - Tan LW
FAU - Adams, Damian
AU  - Adams D
FAU - Varelias, Antiopi
AU  - Varelias A
FAU - Ooi, Eng Hooi
AU  - Ooi EH
FAU - Wormald, Peter-John
AU  - Wormald PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Rhinol
JT  - American journal of rhinology
JID - 8807268
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Cell Count
MH  - Chronic Disease
MH  - *Eosinophilia/immunology/microbiology
MH  - Eosinophils/immunology
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Immunohistochemistry
MH  - Mast Cells/immunology
MH  - Middle Aged
MH  - Mycoses/*immunology
MH  - Nasal Mucosa/cytology/immunology/microbiology
MH  - Respiratory Hypersensitivity/*immunology/*microbiology
MH  - Rhinitis/*immunology/microbiology
MH  - Sinusitis/*immunology/microbiology
MH  - Th2 Cells/*immunology/microbiology
EDAT- 2006/05/12 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/05/12 09:00
PHST- 2006/05/12 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/05/12 09:00 [entrez]
PST - ppublish
SO  - Am J Rhinol. 2006 Mar-Apr;20(2):145-9.