PMID- 16686380
OWN - NLM
STAT- MEDLINE
DCOM- 20061129
LR  - 20171116
IS  - 1050-6586 (Print)
IS  - 1050-6586 (Linking)
VI  - 20
IP  - 2
DP  - 2006 Mar-Apr
TI  - Signals through CD40 play a critical role in the pathophysiology of Schistosoma 
      mansoni egg antigen--induced allergic rhinitis in mice.
PG  - 165-9
AB  - BACKGROUND: Interaction between CD40 and CD40L is thought to regulate immune 
      responses in several allergic diseases. However, little is known about its in 
      vivo role in the pathophysiology of allergic rhinitis. We sought to determine 
      whether the lack of signals through CD40 affects the pathophysiology of allergic 
      rhinitis using a murine model. METHODS: Wild type (WT) and CD40-deficient BALB/c 
      (CD40-/-) mice were sensitized intranasally to Schistosoma mansoni egg antigen 
      (SEA). After repeated sensitization, histamine responsiveness, serum antibody 
      titer including immunoglobulin E (IgE), nasal eosinophilia, and cytokine 
      production by nasal mononuclear cells were determined in each group. RESULTS: 
      Intranasal sensitization with SEA in WT mice elicited a strong Th2 response 
      including SEA-specific IgE production, nasal eosinophilia, and interleukin 
      (IL)-4, and IL-5 production by nasal mononuclear cells after antigen challenge. 
      Production of SEA-specific IgE and IgG1 was abolished in SEA-sensitized CD40-/- 
      mice. These mice showed impaired nasal eosinophilia and displayed markedly 
      reduced histamine-induced nasal hyperresponsiveness as compared with WT mice. 
      Furthermore, reduced production of IL-4 and IL-5 by nasal mononuclear cells was 
      seen in CD40-/- mice. CONCLUSION: These results show that signals through CD40 
      play a critical role in not only IgE production but also pathophysiology of 
      allergic rhinitis such as nasal hyperresponsiveness and nasal eosinophilia.
FAU - Hattori, Hisashi
AU  - Hattori H
AD  - Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA.
FAU - Okano, Mitsuhiro
AU  - Okano M
FAU - Kariya, Shin
AU  - Kariya S
FAU - Nishizaki, Kazunori
AU  - Nishizaki K
FAU - Satoskar, Abhay R
AU  - Satoskar AR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Rhinol
JT  - American journal of rhinology
JID - 8807268
RN  - 0 (Antigens, Helminth)
RN  - 0 (CD40 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antigens, Helminth/*adverse effects/*immunology
MH  - CD40 Antigens/*immunology/metabolism
MH  - Cytokines/biosynthesis/immunology
MH  - Disease Models, Animal
MH  - Eosinophilia/immunology/metabolism/physiopathology
MH  - Female
MH  - Immunization
MH  - Immunoglobulin E/biosynthesis/immunology
MH  - Immunoglobulin G/biosynthesis/immunology
MH  - Leukocytes, Mononuclear/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nasal Mucosa/immunology/metabolism/physiopathology
MH  - Rhinitis, Allergic, Perennial/etiology/*immunology/metabolism/*physiopathology
MH  - Schistosoma mansoni/*immunology
EDAT- 2006/05/12 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/05/12 09:00
PHST- 2006/05/12 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/05/12 09:00 [entrez]
PST - ppublish
SO  - Am J Rhinol. 2006 Mar-Apr;20(2):165-9.