PMID- 16689001
OWN - NLM
STAT- MEDLINE
DCOM- 20080407
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 26
IP  - 4
DP  - 2006 Apr
TI  - [Effects of Jiangtang Bushen Recipe on serum C-reactive protein, tumor necrosis 
      factor-alpha and interleukin-6 in patients with type 2 diabetes mellitus].
PG  - 329-31
AB  - OBJECTIVE To observe the effect of Jiangtang Bushen Recipe (JBR) on inflammatory 
      cytokines in patients with type 2 diabetes mellitus (T2DM), and explore its 
      therapeutic mechanism. METHODS Sixty-four patients with T2DM were randomly 
      divided into the treated group (n = 34) and the control group (n = 30). Education 
      course, dietary treatment and conventional hypoglycemic agent were given to both 
      groups, and JBR, mainly composed of Cibot Rhizome, Radix Dipsaci, Glossy Privet 
      Fruit; Ecliptae Herba, Radicis Lycii, Radix Astragali, Rehmannia Dride Rhizome, 
      etc., was given additionally to patients in the treated group, one dose a day for 
      4 weeks by boiled water and taking in two times. Fasting blood glucose (FBG), 
      fasting insulin (FINS), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and 
      C-reactive protein (CRP) were measured, and insulin sensitive index (ISI) and 
      clinical TCM symptom score were calculated before and after treatment. RESULTS: 
      After treatment, the clinical symptom score dropped in both groups (P < 0.01), 
      and it was lower in the treated group than that in the control group (P < 0.01). 
      At the same time, serum levels of FINS, CRP, TNF-alpha and IL-6 decreased and ISI 
      increased significantly, the effect showed in the treated group was also superior 
      to that in the control group (P < 0.05). CONCLUSION: JBR, which could tonify Pi 
      and Shen, nourish Yin and clear away heat, can improve insulin resistance and 
      alleviate clinical symptoms of T2DM patients, the mechanism may be related with 
      its actions in regulating the production of inflammatory cytokines and inhibiting 
      inflammatory reac-
FAU - Fan, Guan-jie
AU  - Fan GJ
AD  - Department of Endocrinology, Guangdong Provincial Hospital of Traditional Chinese 
      Medicine, Guangzhou 510120. fgjie@tom.com
FAU - Tang, Xian-yu
AU  - Tang XY
FAU - Li, Shuang-lei
AU  - Li SL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (jiangtang bushen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - C-Reactive Protein/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - *Phytotherapy
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2006/05/13 09:00
MHDA- 2008/04/09 09:00
CRDT- 2006/05/13 09:00
PHST- 2006/05/13 09:00 [pubmed]
PHST- 2008/04/09 09:00 [medline]
PHST- 2006/05/13 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Apr;26(4):329-31.