PMID- 16690200
OWN - NLM
STAT- MEDLINE
DCOM- 20070123
LR  - 20101118
IS  - 0300-9084 (Print)
IS  - 0300-9084 (Linking)
VI  - 88
IP  - 9
DP  - 2006 Sep
TI  - The increased accumulation of structurally modified versican and decorin is 
      related with the progression of laryngeal cancer.
PG  - 1135-43
AB  - Versican and decorin, two proteoglycans (PGs) with contradictory roles in the 
      pathophysiology of cancer, comprise important stromal components in many tumor 
      types and play a crucial role in the progression of cancer. In this study, we 
      provide direct evidence for a significant and stage-related accumulation of 
      versican and decorin in the tumor-associated stroma of laryngeal squamous cell 
      carcinoma (LSCC) in comparison to normal larynx. Both PGs were found to be 
      co-localized within the peritumorous stroma. In addition, the accumulated 
      versican and decorin were markedly modified on both protein core and 
      glycosaminoglycan (GAG) levels. Decorin, which was present under both glycanated 
      and non-glycanated forms, perceptibly increased with the progression of LSCC, 
      compared to the normal larynx. Tumor-associated glycanated decorin was found to 
      contain significant amounts of dermatan sulfate (DS) sequences. Versican was also 
      found to undergo stage-related structural modifications since a marked 
      heterogeneity of protein cores was observed, being intense in late stage of 
      laryngeal cancer. The increased accumulation of both versican and decorin was 
      associated with a significant stage-related increase of the molar ratio of Delta 
      di-mono4S to Delta di-mono6S up to approximately threefold in LSCC compared to 
      the normal ones. The modified chemical structure of both PGs could be associated 
      with the degree of aggressiveness of laryngeal squamous cell carcinomas.
FAU - Skandalis, S S
AU  - Skandalis SS
AD  - Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and 
      Natural Products, Department of Chemistry, University of Patras, 26500 Patras, 
      Greece. s_skandal@hotmail.com
FAU - Theocharis, A D
AU  - Theocharis AD
FAU - Papageorgakopoulou, N
AU  - Papageorgakopoulou N
FAU - Vynios, D H
AU  - Vynios DH
FAU - Theocharis, D A
AU  - Theocharis DA
LA  - eng
PT  - Journal Article
DEP - 20060425
PL  - France
TA  - Biochimie
JT  - Biochimie
JID - 1264604
RN  - 0 (DCN protein, human)
RN  - 0 (Decorin)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Proteoglycans)
RN  - 0 (Uronic Acids)
RN  - 126968-45-4 (Versicans)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Decorin
MH  - Disease Progression
MH  - Extracellular Matrix Proteins/chemistry/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/chemistry/*metabolism/pathology
MH  - Larynx/metabolism/pathology
MH  - *Protein Processing, Post-Translational
MH  - Proteoglycans/chemistry/*metabolism
MH  - Up-Regulation
MH  - Uronic Acids/analysis
MH  - Versicans/chemistry/*metabolism
EDAT- 2006/05/13 09:00
MHDA- 2007/01/24 09:00
CRDT- 2006/05/13 09:00
PHST- 2006/01/20 00:00 [received]
PHST- 2006/03/30 00:00 [accepted]
PHST- 2006/05/13 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2006/05/13 09:00 [entrez]
AID - S0300-9084(06)00048-4 [pii]
AID - 10.1016/j.biochi.2006.03.011 [doi]
PST - ppublish
SO  - Biochimie. 2006 Sep;88(9):1135-43. doi: 10.1016/j.biochi.2006.03.011. Epub 2006 
      Apr 25.