PMID- 16690414
OWN - NLM
STAT- MEDLINE
DCOM- 20060703
LR  - 20220408
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 12
DP  - 2005 Dec
TI  - Association of interleukin-10 A-592C and T-819C polymorphisms with type 2 
      diabetes mellitus.
PG  - 1258-63
AB  - Type 2 diabetes mellitus (T2DM) is the most common form of diabetes. The 
      association of low interleukin (IL)-10 production capacity with the metabolic 
      syndrome and T2DM was recently established. Approximately 75% of the variation in 
      IL-10 secretion capacity in humans derives from genetic factors that contribute 
      to disease susceptibility. Based on the facts that IL-10 secretion ability is 
      tightly controlled at the transcription level and the low production capacity of 
      IL-10 is associated with T2DM, it seemed tempting to investigate if polymorphisms 
      in the IL-10 gene promoter contribute to T2DM. IL-10 promoter polymorphisms at 
      positions -592 and -819 among 370 consecutive patients with T2DM seen at the 
      Department of Internal Medicine, Chung Shan Medical University Hospital, were 
      examined using polymerase chain reaction restriction fragment length 
      polymorphism. Though no significant association was detected between either the 
      A-592C (p=0.088) or T-819C (p=0.160) polymorphism and T2DM, significantly more 
      T2DM subjects carried -592*C (34.28%, p=0.027) and -819*C (32.57%, p<0.001) 
      alleles, which were associated with high levels of IL-10 production. 
      Nevertheless, no association was observed between these two polymorphisms and 
      biochemical markers for T2DM. Our study suggests that IL-10 genetic polymorphisms 
      may play a specific role(s) in determining diabetic susceptibility, but do not 
      seem to be important in the clinical manifestations of diabetes.
FAU - Chang, Yih-Hsin
AU  - Chang YH
AD  - School of Medical Laboratory and Biotechnology, Chung Shan Medical University, 
      and Department of Internal Medicine, Chung Shan Medical University Hospital, 
      Taichung, Taiwan, ROC.
FAU - Huang, Chien-Ning
AU  - Huang CN
FAU - Wu, Chuan-Yin
AU  - Wu CY
FAU - Shiau, Ming-Yuh
AU  - Shiau MY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060313
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*epidemiology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-10/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Taiwan/epidemiology
EDAT- 2006/05/13 09:00
MHDA- 2006/07/04 09:00
CRDT- 2006/05/13 09:00
PHST- 2005/03/30 00:00 [received]
PHST- 2005/05/09 00:00 [accepted]
PHST- 2006/05/13 09:00 [pubmed]
PHST- 2006/07/04 09:00 [medline]
PHST- 2006/05/13 09:00 [entrez]
AID - S0198-8859(05)00099-6 [pii]
AID - 10.1016/j.humimm.2005.05.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Dec;66(12):1258-63. doi: 10.1016/j.humimm.2005.05.001. Epub 
      2006 Mar 13.