PMID- 16696738
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20220408
IS  - 0002-8614 (Print)
IS  - 0002-8614 (Linking)
VI  - 54
IP  - 5
DP  - 2006 May
TI  - Meaningful change and responsiveness in common physical performance measures in 
      older adults.
PG  - 743-9
AB  - OBJECTIVES: To estimate the magnitude of small meaningful and substantial 
      individual change in physical performance measures and evaluate their 
      responsiveness. DESIGN: Secondary data analyses using distribution- and 
      anchor-based methods to determine meaningful change. SETTING: Secondary analysis 
      of data from an observational study and clinical trials of community-dwelling 
      older people and subacute stroke survivors. PARTICIPANTS: Older adults with 
      mobility disabilities in a strength training trial (n=100), subacute stroke 
      survivors in an intervention trial (n=100), and a prospective cohort of 
      community-dwelling older people (n=492). MEASUREMENTS: Gait speed, Short Physical 
      Performance Battery (SPPB), 6-minute-walk distance (6MWD), and self-reported 
      mobility. RESULTS: Most small meaningful change estimates ranged from 0.04 to 
      0.06 m/s for gait speed, 0.27 to 0.55 points for SPPB, and 19 to 22 m for 6MWD. 
      Most substantial change estimates ranged from 0.08 to 0.14 m/s for gait speed, 
      0.99 to 1.34 points for SPPB, and 47 to 49 m for 6MWD. Based on responsiveness 
      indices, per-group sample sizes for clinical trials ranged from 13 to 42 for 
      substantial change and 71 to 161 for small meaningful change. CONCLUSION: Best 
      initial estimates of small meaningful change are near 0.05 m/s for gait speed, 
      0.5 points for SPPB, and 20 m for 6MWD and of substantial change are near 0.10 
      m/s for gait speed, 1.0 point for SPPB, and 50 m for 6MWD. For clinical use, 
      substantial change in these measures and small change in gait speed and 6MWD, but 
      not SPPB, are detectable. For research use, these measures yield feasible sample 
      sizes for detecting meaningful change.
FAU - Perera, Subashan
AU  - Perera S
AD  - Division of Geriatric Medicine and Department of Biostatistics, Univeristy of 
      Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA. pereras@dom.pitt.edu
FAU - Mody, Samir H
AU  - Mody SH
FAU - Woodman, Richard C
AU  - Woodman RC
FAU - Studenski, Stephanie A
AU  - Studenski SA
LA  - eng
GR  - K07 AG 023641/AG/NIA NIH HHS/United States
GR  - P30 AG 014827/AG/NIA NIH HHS/United States
GR  - P60 AG 14635/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Exercise Test
MH  - Female
MH  - Gait/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mobility Limitation
MH  - Psychomotor Performance/*physiology
MH  - Recovery of Function/*physiology
MH  - Stroke/*physiopathology
MH  - Stroke Rehabilitation
MH  - Walking/*physiology
EDAT- 2006/05/16 09:00
MHDA- 2006/06/14 09:00
CRDT- 2006/05/16 09:00
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - JGS701 [pii]
AID - 10.1111/j.1532-5415.2006.00701.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2006 May;54(5):743-9. doi: 10.1111/j.1532-5415.2006.00701.x.