PMID- 16696740
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20080310
IS  - 0002-8614 (Print)
IS  - 0002-8614 (Linking)
VI  - 54
IP  - 5
DP  - 2006 May
TI  - Alcohol use, comorbidity, and mortality.
PG  - 757-62
AB  - OBJECTIVES: To examine the combined influence of alcohol use and comorbidity on 
      20-year mortality in older adults (average age 66 at the time of the baseline 
      survey). DESIGN: Longitudinal analysis of a national probability sample-based 
      cohort study. SETTING: Data sources were the National Health and Nutrition 
      Examination Survey I (NHANES I), 1971-1974, and the NHANES Epidemiologic Followup 
      Survey, 1992. PARTICIPANTS: Four thousand six hundred ninety-one adults aged 60 
      and older who provided data on alcohol use. MEASUREMENTS: The prevalence of 
      at-risk drinking in older adults in the United States and the 20-year all-cause 
      mortality risk associated with it. At-risk drinking status was determined from 
      amount of alcohol consumed and comorbidities, using a previously validated 
      method. RESULTS: The prevalence of at-risk drinking in the United States between 
      1971 and 1974 in older adults was 10% (18% of men, 5% of women). The majority of 
      at-risk drinkers were identified as such because of their use of alcohol in 
      amounts deemed risky in the presence of relevant comorbidities (69%) (e.g., 
      drinking 2-3 drinks per day and having gout or anxiety or taking a medication for 
      pain). In men, at-risk drinking was associated with higher mortality rates than 
      not-at-risk drinking (hazard ratio=1.20, 95% confidence interval=1.01-1.41); 
      abstinence was not associated with greater mortality. In women, neither 
      abstinence nor at-risk drinking was associated with greater mortality rates. 
      CONCLUSION: In this first, large population-based study of older adults examining 
      the mortality risks of alcohol use and comorbidity, at-risk drinking was 
      associated with greater mortality rates in men. These findings suggest that a 
      lower threshold of alcohol use should be recommended for older adults with 
      specific comorbidities to reduce mortality risks.
FAU - Moore, Alison A
AU  - Moore AA
AD  - Department of Medicine, Division of Geriatrics, David Geffen School of Medicine, 
      University of California at Los Angeles, 10945 Le Conte Avenue, Los Angeles, CA 
      90095, USA. aamoore@mednet.ucla.edu
FAU - Giuli, Lisa
AU  - Giuli L
FAU - Gould, Robert
AU  - Gould R
FAU - Hu, Peifeng
AU  - Hu P
FAU - Zhou, Kefei
AU  - Zhou K
FAU - Reuben, David
AU  - Reuben D
FAU - Greendale, Gail
AU  - Greendale G
FAU - Karlamangla, Arun
AU  - Karlamangla A
LA  - eng
GR  - K12 AG 01004/AG/NIA NIH HHS/United States
GR  - K23 AA 00270/AA/NIAAA NIH HHS/United States
GR  - K23 AG 021029/AG/NIA NIH HHS/United States
GR  - P30 AG 21684/AG/NIA NIH HHS/United States
GR  - P60 AG 10415-13/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
CIN - J Am Geriatr Soc. 2006 Dec;54(12):1947-8; author reply 1948-9. PMID: 17198507
MH  - Aged
MH  - Alcohol Drinking/*mortality
MH  - Cohort Studies
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Prevalence
MH  - *Risk-Taking
MH  - Socioeconomic Factors
MH  - Survival Rate
MH  - United States/epidemiology
EDAT- 2006/05/16 09:00
MHDA- 2006/06/14 09:00
CRDT- 2006/05/16 09:00
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - JGS728 [pii]
AID - 10.1111/j.1532-5415.2006.00728.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2006 May;54(5):757-62. doi: 10.1111/j.1532-5415.2006.00728.x.