PMID- 16696953
OWN - NLM
STAT- MEDLINE
DCOM- 20060919
LR  - 20220410
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1092
IP  - 1
DP  - 2006 May 30
TI  - Effects of electroacupuncture on retinal nerve growth factor and brain-derived 
      neurotrophic factor expression in a rat model of retinitis pigmentosa.
PG  - 198-206
AB  - The aim of this study was to investigate the effect of electroacupuncture (EA) on 
      the progression of retinal degeneration in rats affected by inherited retinitis 
      pigmentosa (IRP) and to correlate this event with the retinal expression of 
      neurotrophins. Thirty-day-old Royal College of Surgeons (RCS) rats were exposed 
      to 25-min-long daily sessions of low-frequency EA for 11 consecutive days. 
      Control-untreated and EA-treated rats were sacrificed 1 h after the last EA 
      session, and their retina removed for biochemical, molecular, and 
      immunohistochemical analyses. Our data revealed that daily sessions of 
      low-frequency EA for 11 days to RCS rats during a critical developmental stage of 
      retinal cell degeneration cause an increase of retinal nerve growth factor (NGF) 
      and NGF high-affinity receptor (TrkA) expression; and increase of outer nuclear 
      layer (ONL) thickness; and enhanced vascularization. These findings suggest the 
      possible beneficial effects of EA treatment in the development of IRP-like 
      retinal degeneration of RCS rats and that the mechanism through which EA might 
      exerts its action on the regulation of NGF and brain-derived neurotrophic factor 
      (BDNF) and/or their receptors in retinal cells.
FAU - Pagani, Lucia
AU  - Pagani L
AD  - Institute of Neurobiology and Molecular Medicine, NGF Section, CNR-EBRI, Via del 
      Fosso di Fiorano, 64, 00143 Rome, Italy.
FAU - Manni, Luigi
AU  - Manni L
FAU - Aloe, Luigi
AU  - Aloe L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060511
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkA)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Electroacupuncture/*methods
MH  - Neovascularization, Physiologic/physiology
MH  - Nerve Growth Factor/*metabolism
MH  - Neurons/metabolism/pathology
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkA/metabolism
MH  - Retina/*metabolism/physiopathology
MH  - Retinal Artery/anatomy & histology/physiology
MH  - Retinitis Pigmentosa/*metabolism/physiopathology/*therapy
MH  - Treatment Outcome
MH  - Up-Regulation/physiology
EDAT- 2006/05/16 09:00
MHDA- 2006/09/20 09:00
CRDT- 2006/05/16 09:00
PHST- 2005/12/21 00:00 [received]
PHST- 2006/03/17 00:00 [revised]
PHST- 2006/03/20 00:00 [accepted]
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2006/09/20 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - S0006-8993(06)00851-1 [pii]
AID - 10.1016/j.brainres.2006.03.074 [doi]
PST - ppublish
SO  - Brain Res. 2006 May 30;1092(1):198-206. doi: 10.1016/j.brainres.2006.03.074. Epub 
      2006 May 11.