PMID- 16697654
OWN - NLM
STAT- MEDLINE
DCOM- 20060814
LR  - 20061115
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 34
IP  - 1-2
DP  - 2006 Apr
TI  - HIV-infected patients with lipodystrophy have higher rates of carotid 
      atherosclerosis: the role of monocyte chemoattractant protein-1.
PG  - 51-5
AB  - Individuals with HIV-1 infection are at increased risk for cardiovascular events, 
      and lipodystrophy is generally associated with pro-atherogenic metabolic 
      disturbances. We conducted a case-control study to assess the presence of 
      sub-clinical atherosclerosis in HIV-1-infected patients with or without 
      lipodystrophy (LD) and to evaluate the influence of monocyte chemoattractant 
      protein-1 (MCP-1) on the development of both carotid atherosclerosis and LD. The 
      study population consisted of 43 patients with LD and 86 patients without LD. We 
      determined carotid intima-media thickness (IMT), MCP-1 concentrations in plasma, 
      and MCP-1 genotype (presence or absence of the -2518G allele). HIV-1-infected 
      patients with LD showed increased risk (OR=3.71, 95% CI=1.10-12.47, p=0.03) for 
      sub-clinical atherosclerosis, and MCP-1 plasma concentration was significantly 
      correlated with IMT in these patients (Pearson=0.31, p=0.03). Furthermore, 
      presence of LD was a determinant for MCP-1 plasma concentration (beta=0.18, 
      p=0.05). In summary, HIV-1-infected patients with clinically manifest LD are at 
      higher risk for atherosclerosis and our observations support the relationship 
      between inflammation and atherosclerotic disease.
FAU - Coll, Blai
AU  - Coll B
AD  - Servei de Medicina Interna, Hospital Universitari Sant Joan, Reus, Spain. 
      bcoll@grupsagessa.com
FAU - Parra, Sandra
AU  - Parra S
FAU - Alonso-Villaverde, Carlos
AU  - Alonso-Villaverde C
FAU - de Groot, Eric
AU  - de Groot E
FAU - Aragones, Gerard
AU  - Aragones G
FAU - Montero, Manuel
AU  - Montero M
FAU - Tous, Monica
AU  - Tous M
FAU - Camps, Jordi
AU  - Camps J
FAU - Joven, Jorge
AU  - Joven J
FAU - Masana, Lluis
AU  - Masana L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060512
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Atherosclerosis
MH  - Carotid Arteries/pathology
MH  - Carotid Artery Diseases/complications/*pathology
MH  - Case-Control Studies
MH  - Chemokine CCL2/*metabolism
MH  - Female
MH  - HIV Infections/complications/*pathology
MH  - Humans
MH  - Lipodystrophy/complications/*pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Tunica Intima/pathology
EDAT- 2006/05/16 09:00
MHDA- 2006/08/15 09:00
CRDT- 2006/05/16 09:00
PHST- 2005/11/15 00:00 [received]
PHST- 2006/02/01 00:00 [revised]
PHST- 2006/03/29 00:00 [accepted]
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2006/08/15 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - S1043-4666(06)00134-7 [pii]
AID - 10.1016/j.cyto.2006.03.013 [doi]
PST - ppublish
SO  - Cytokine. 2006 Apr;34(1-2):51-5. doi: 10.1016/j.cyto.2006.03.013. Epub 2006 May 
      12.