PMID- 16698432
OWN - NLM
STAT- MEDLINE
DCOM- 20060829
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 1-2
DP  - 2006 Jan-Feb
TI  - A family based linkage analysis of HLA and 5-HTTLPR gene polymorphisms in 
      Sardinian children with autism spectrum disorder.
PG  - 108-17
AB  - Autism spectrum disorders (ASD) are characterized by a broad range in clinical 
      presentation. Although a definite genetic cause has not yet been fully 
      demonstrated, family based studies suggest that a multigenic pattern may be 
      responsible for susceptibility, but most results are conflicting and have yet to 
      be replicated. The purpose of this investigation was to analyze the linkage of 
      the human leukocyte antigen (HLA) and the human serotonin transporter coding 
      (5-HTTLPR) genes with ASD in a group of 37 families of Sardinian ethnicity in 
      insular Italy. In 50% of these families, ASD is linked to HLA, and in the other 
      50% it is linked to 5-HTTLPR polymorphic genes; in other words, linkage to one or 
      the other was evident in all cases. Despite a very homogenous genetic pattern 
      being generally reported for Sardinians, the linkage observed with HLA and 
      5-HTTLPR genetic regions indicated a statistically defined heterogeneity 
      (p=0.002). No allelic HLA or 5-HTTLPR polymorphisms were specifically associated 
      with ASD, suggesting these loci as markers of other genes mapped in their close 
      proximity that may be more directly involved and thus may merit further 
      analytical studies.
FAU - Guerini, Franca R
AU  - Guerini FR
AD  - Laboratory of Molecular Medicine and Biotechnologies, Don C. Gnocchi Foundation 
      IRCCS, S. Maria Nascente, Milan, Italy.
FAU - Manca, Salvatorica
AU  - Manca S
FAU - Sotgiu, Stefano
AU  - Sotgiu S
FAU - Tremolada, Sara
AU  - Tremolada S
FAU - Zanzottera, Milena
AU  - Zanzottera M
FAU - Agliardi, Cristina
AU  - Agliardi C
FAU - Zanetta, Lorenzo
AU  - Zanetta L
FAU - Saresella, Marina
AU  - Saresella M
FAU - Mancuso, Roberta
AU  - Mancuso R
FAU - De Silvestri, Annalisa
AU  - De Silvestri A
FAU - Fois, Maria Laura
AU  - Fois ML
FAU - Arru, Giannina
AU  - Arru G
FAU - Ferrante, Pasquale
AU  - Ferrante P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060406
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Adolescent
MH  - Autistic Disorder/*epidemiology/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Ethnicity/*genetics
MH  - Female
MH  - Genetic Linkage
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Italy/epidemiology/ethnology
MH  - Male
MH  - Molecular Epidemiology
MH  - *Polymorphism, Genetic
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
EDAT- 2006/05/16 09:00
MHDA- 2006/08/30 09:00
CRDT- 2006/05/16 09:00
PHST- 2005/12/01 00:00 [received]
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2006/08/30 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - S0198-8859(06)00018-8 [pii]
AID - 10.1016/j.humimm.2006.02.033 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Jan-Feb;67(1-2):108-17. doi: 10.1016/j.humimm.2006.02.033. Epub 
      2006 Apr 6.