PMID- 16698437
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 3
DP  - 2006 Mar
TI  - Diversity of MICA and linkage disequilibrium with HLA-B in two North American 
      populations.
PG  - 152-8
AB  - The MICA gene has a high degree of polymorphism. Allelic variation of MICA may 
      influence binding of these ligands to the NK cell receptor NKG2D and may affect 
      organ transplantation and/or disease pathogenesis. Knowledge of the population 
      distribution of MICA alleles and their linkage disequilibrium (LD) with class I 
      human leukocyte antigen (HLA) will enhance our understanding of the potential 
      functional significance of the MICA polymorphism. In the present study, we 
      characterized the MICA and HLA-B polymorphisms in two North American populations: 
      European and African. The individual racial groups showed rather limited 
      variation at the MICA locus, where the same set of three most common alleles, 
      MICA*00201, *004, and *00801, account for 64 and 71% of the allele frequency in 
      European-Americans and African-Americans, respectively. Other common alleles 
      (allele frequency >5% in a population) include MICA*00901 and *010. MICA alleles 
      showed strong linkage disequilibrium with HLA-B. Typically, a common MICA allele 
      has strong LD with several HLA-B alleles, whereas most HLA-B alleles and their 
      related serological groups are associated with a single MICA allele. The lack of 
      evidence for an active diversification of the MICA gene after racial separation 
      indicates an evolutionary history distinct from that of the classical HLA genes.
FAU - Gao, Xiaojiang
AU  - Gao X
AD  - Laboratory of Genomic Diversity, NCI-Frederick, Basic Research Program, SAIC 
      Frederick, Frederick, MD 21702, USA.
FAU - Single, Richard M
AU  - Single RM
FAU - Karacki, Peter
AU  - Karacki P
FAU - Marti, Darlene
AU  - Marti D
FAU - O'Brien, Stephen J
AU  - O'Brien SJ
FAU - Carrington, Mary
AU  - Carrington M
LA  - eng
GR  - N01-CO12400/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060331
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - B-Lymphocytes/metabolism
MH  - *Black People
MH  - Cell Line
MH  - Gene Frequency
MH  - HIV Infections/immunology
MH  - HLA-B Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - *Linkage Disequilibrium
MH  - *Polymorphism, Genetic
MH  - *White People
EDAT- 2006/05/16 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/05/16 09:00
PHST- 2005/05/20 00:00 [received]
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - S0198-8859(06)00030-9 [pii]
AID - 10.1016/j.humimm.2006.02.009 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Mar;67(3):152-8. doi: 10.1016/j.humimm.2006.02.009. Epub 2006 
      Mar 31.