PMID- 16698442
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20071114
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 3
DP  - 2006 Mar
TI  - MHC class I chain-related gene a diversity in head and neck squamous cell 
      carcinoma.
PG  - 196-203
AB  - Many immune-related genes are located within the human leukocyte antigen (HLA) 
      region on chromosome 6. The MHC class I chain-related gene A (MICA), located 
      centromeric of HLA-B, is involved in the innate and adaptive immune response 
      through activation of NK and T cells. Differences of MICA transmembrane repeat 
      lengths have been associated with diseases and expression is observed on 
      epithelial tumors. Head and neck squamous cell carcinoma (HNSCC) is an epithelial 
      tumor. In the present study we evaluated the MICA repeat length diversity in 
      relation to MICA expression in Dutch HNSCC patients. MICA short tandem repeat 
      analysis indicated a significant decrease in the frequency for the MICA-A9 repeat 
      in patients diagnosed with oral cavity squamous cell carcinoma (SCC) but not in 
      patients with SCC in the hypoharynx, larynx, or oropharynx. Interestingly, the 
      majority of patients expressed MICA as observed with immunohistochemical staining 
      whereas no soluble MICA was detected in patients' sera by enzyme-linked 
      immunosorbent assay. In conclusion, the length of the MICA transmembrane repeats 
      in Dutch HNSCC patients does not influence the MICA expression on tumor cells.
FAU - Reinders, Judith
AU  - Reinders J
AD  - Department of Pathology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Rozemuller, Erik H
AU  - Rozemuller EH
FAU - van der Ven, Kevin J W
AU  - van der Ven KJ
FAU - Caillat-Zucman, Sophie
AU  - Caillat-Zucman S
FAU - Slootweg, Pieter J
AU  - Slootweg PJ
FAU - de Weger, Roel A
AU  - de Weger RA
FAU - Tilanus, Marcel G J
AU  - Tilanus MG
LA  - eng
GR  - 1-U24 AI49213/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060329
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Carcinoma, Squamous Cell/blood/genetics/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Head and Neck Neoplasms/blood/genetics/*metabolism
MH  - Histocompatibility Antigens Class I/blood/genetics/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Tandem Repeat Sequences
EDAT- 2006/05/16 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/05/16 09:00
PHST- 2005/03/02 00:00 [received]
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - S0198-8859(06)00027-9 [pii]
AID - 10.1016/j.humimm.2006.02.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Mar;67(3):196-203. doi: 10.1016/j.humimm.2006.02.006. Epub 2006 
      Mar 29.