PMID- 16698446
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20061115
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 3
DP  - 2006 Mar
TI  - Frequency of MIC antibody in rejected renal transplant patients without HLA 
      antibody.
PG  - 223-9
AB  - Antibodies to MICA and MICB antigens were sought in the sera of 139 kidney 
      transplant recipients. MICA*001, *002, *007, *008, and MICB*002 antigens were 
      produced in Escherichia coli and then tested using enzyme-linked immunosorbent 
      assay plates. Among 35 normal sera, 6% had MIC antibodies, and among 14 sera from 
      pregnant women, 21% had MIC antibodies. Among 34 patients with functioning 
      transplants with human leukocyte antigen (HLA) antibodies, 24% had MIC 
      antibodies, and 19% of 32 patients without HLA antibodies had MIC antibodies. 
      Among 46 patients who lost grafts with HLA antibodies, 26% had MIC antibodies, 
      and among 27 failed patients without HLA antibodies, 37% had MIC antibodies. We 
      conclude that antibodies to MIC are produced in the course of immunization by 
      pregnancies and kidney transplants. They also occurred more frequently in 
      rejected patients (30%) than in those with functioning grafts (21%).
FAU - Mizutani, Kazuo
AU  - Mizutani K
AD  - Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA. 
      kazuomizutani@terasakilab.org
FAU - Terasaki, Paul I
AU  - Terasaki PI
FAU - Shih, Remi N J
AU  - Shih RN
FAU - Pei, Rui
AU  - Pei R
FAU - Ozawa, Miyuki
AU  - Ozawa M
FAU - Lee, Jarhow
AU  - Lee J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060331
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Isoantibodies)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (MICB antigen)
SB  - IM
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Graft Rejection/*immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Isoantibodies/immunology
MH  - Kidney Transplantation/*immunology
MH  - Pregnancy
MH  - Retrospective Studies
EDAT- 2006/05/16 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/05/16 09:00
PHST- 2005/05/02 00:00 [received]
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - S0198-8859(06)00028-0 [pii]
AID - 10.1016/j.humimm.2006.02.007 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Mar;67(3):223-9. doi: 10.1016/j.humimm.2006.02.007. Epub 2006 
      Mar 31.