PMID- 16698448
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20061115
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 3
DP  - 2006 Mar
TI  - MICA, MICB, and MHC beta block matching in bone marrow transplantation: relevance 
      to transplantation outcome.
PG  - 238-46
AB  - Genetic testing of the MHC is required for selection of donors for bone marrow 
      transplantation. The outcome of related bone marrow transplantation is usually 
      superior to that of unrelated bone marrow transplantation. This may be the result 
      of inaccurate or incomplete genetic testing employed for selection of donor for 
      transplantation. Based on MHC haplotype matching, MHC block matching has been 
      developed for selection of potential unrelated donor. Block matching has been 
      shown previously to improve outcome when added to the conventional method of 
      human leukocyte antigen (HLA) typing for selection of donors. In this study, we 
      have retrospectively analyzed 44 donor recipient pairs from the Australian Bone 
      Marrow Donor Registry Repository with respect to matching of HLA-B and HLA-Cw by 
      sequence-based typing and MICA and MICB by polymerase chain reaction-sequence 
      specific primer and MHC beta block matching and correlated these results with 
      survival. Beta block matching was correlated with MIC matching (p < 0.005) and 
      with HLA-B and HLA-Cw matching. Patients who were HLA-B and -Cw matched had 
      significantly improved survival when they were additionally matched for MHC beta 
      block (p(c) = 0.04) or MIC (p(c) = 0.05).
FAU - Kitcharoen, K
AU  - Kitcharoen K
AD  - Medical Technology Program, Faculty of Medical Technology, Mahidol University, 
      Bangkok 10700, Thailand.
FAU - Witt, C S
AU  - Witt CS
FAU - Romphruk, A V
AU  - Romphruk AV
FAU - Christiansen, F T
AU  - Christiansen FT
FAU - Leelayuwat, C
AU  - Leelayuwat C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060329
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (MICB antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bone Marrow Transplantation/*immunology/mortality
MH  - Child
MH  - Donor Selection
MH  - Female
MH  - HLA-B Antigens/*immunology
MH  - HLA-C Antigens/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Major Histocompatibility Complex/*immunology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Transplantation Tolerance
EDAT- 2006/05/16 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/05/16 09:00
PHST- 2005/06/10 00:00 [received]
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - S0198-8859(06)00033-4 [pii]
AID - 10.1016/j.humimm.2006.02.012 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Mar;67(3):238-46. doi: 10.1016/j.humimm.2006.02.012. Epub 2006 
      Mar 29.