PMID- 16699804
OWN - NLM
STAT- MEDLINE
DCOM- 20070126
LR  - 20211020
IS  - 0256-7040 (Print)
IS  - 0256-7040 (Linking)
VI  - 22
IP  - 10
DP  - 2006 Oct
TI  - Cerebrospinal fluid obstruction and malabsorption in human neonatal hydrocephaly.
PG  - 1249-55
AB  - INTRODUCTION: The pathophysiology involved in human neonatal high-pressure 
      hydrocephalus (HC) includes both cerebrospinal fluid (CSF) malabsorption and 
      obstruction. OBJECTIVE: The aim was to estimate the relative contribution between 
      CSF malabsorption and obstruction in three different etiological groups of 
      neonatal high-pressure HC by assessment of specific CSF biomarkers indicative of 
      growth factor- and fibrosis-related CSF malabsorption (transforming growth factor 
      beta-1 (TGF beta-1), aminoterminal propeptide of type 1 collagen (PC1NP)]. 
      MATERIALS AND METHODS: Patients were subdivided into three groups. Group A: spina 
      bifida HC (n=12); group B: non-haemorrhagic triventricular HC (n=4); and group C: 
      posthaemorrhagic HC (n=6). To exclude for confounding differences in 
      pro-inflammatory state between the three groups, interleukin-6 (IL-6) CSF 
      concentrations were assessed. Consecutively, the CSF concentrations of TGF beta-1 
      and PC1NP were compared between the different groups. RESULTS: Median CSF 
      concentrations of IL-6 were low and did not differ between groups. Median CSF 
      concentrations of PC1NP were significantly lower in group A (median: 180 ng/ml, 
      range 90-808) than in group C (median: 1,060, range 396-1194; p=0.002). TGF 
      beta-1 concentrations were significantly higher in group C (median 355 pg/ml, 
      range 129-843) than in groups A (median 103, range 78-675 pg/ml) and B (median 
      120 pg/ml, range 91-188; p=0.01 and 0.03, respectively). CONCLUSIONS: In neonatal 
      posthaemorrhagic HC, high concentrations of malabsorption-related biomarkers 
      contrast with lower concentrations in SB and non-haemorrhagic triventricular HC. 
      During the early development of high pressure HC in SB neonates, CSF biomarkers 
      strongly indicate that CSF obstruction contributes more to the development of HC 
      than malabsorption.
FAU - Heep, Axel
AU  - Heep A
AD  - Department of Neonatology, University of Bonn, Adenauerallee 119, 53113, Bonn, 
      Germany. axel.heep@ukb.uni-bonn.de
FAU - Bartmann, Peter
AU  - Bartmann P
FAU - Stoffel-Wagner, Birgit
AU  - Stoffel-Wagner B
FAU - Bos, Arie
AU  - Bos A
FAU - Hoving, Eelco
AU  - Hoving E
FAU - Brouwer, Oebele
AU  - Brouwer O
FAU - Teelken, Albert
AU  - Teelken A
FAU - Schaller, Carlo
AU  - Schaller C
FAU - Sival, Deborah
AU  - Sival D
LA  - eng
PT  - Journal Article
DEP - 20060513
PL  - Germany
TA  - Childs Nerv Syst
JT  - Child's nervous system : ChNS : official journal of the International Society for 
      Pediatric Neurosurgery
JID - 8503227
RN  - 0 (Collagen Type I)
RN  - 0 (Fetal Proteins)
RN  - 0 (Interleukin-6)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (procollagen Type I N-terminal peptide)
SB  - IM
MH  - Collagen Type I/cerebrospinal fluid
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fetal Proteins/cerebrospinal fluid
MH  - Humans
MH  - Hydrocephalus/*cerebrospinal fluid/*diagnosis
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Premature, Diseases/*cerebrospinal fluid
MH  - Interleukin-6/cerebrospinal fluid
MH  - Male
MH  - Peptide Fragments
MH  - Procollagen
MH  - Retrospective Studies
MH  - Transforming Growth Factor beta1/cerebrospinal fluid
EDAT- 2006/05/16 09:00
MHDA- 2007/01/27 09:00
CRDT- 2006/05/16 09:00
PHST- 2005/07/29 00:00 [received]
PHST- 2005/11/07 00:00 [revised]
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2007/01/27 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
AID - 10.1007/s00381-006-0102-y [doi]
PST - ppublish
SO  - Childs Nerv Syst. 2006 Oct;22(10):1249-55. doi: 10.1007/s00381-006-0102-y. Epub 
      2006 May 13.