PMID- 16700047
OWN - NLM
STAT- MEDLINE
DCOM- 20070109
LR  - 20181113
IS  - 1545-5009 (Print)
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 47
IP  - 3
DP  - 2006 Sep
TI  - Age distributions, birth weights, nephrogenic rests, and heterogeneity in the 
      pathogenesis of Wilms tumor.
PG  - 260-7
AB  - BACKGROUND: The National Wilms Tumor Study (NWTS) constitutes a unique resource 
      for study of clinical, pathologic, and epidemiologic features of Wilms tumor 
      (WT). PROCEDURE: Data from NWTS-3,4,5 were compiled for 7,455 patients with 
      tumors of favorable (FH) or anaplastic (AH) histology. The associations of birth 
      weight (BW) and age-at-onset with gender, intralobar (ILNR), and perilobar (PLNR) 
      nephrogenic rests, tumor focality, congenital malformation syndromes, and tumor 
      histology were analyzed using descriptive statistics and linear regression. 
      RESULTS: Mean BWs for male and female patients without PLNR were 3.52 and 3.36 
      kg, respectively, and for those with PLNR were 0.12 kg and 0.15 kg heavier. Mean 
      age was 45 months for males with no rests whose tumors were unifocal and of 
      triphasic favorable histology. ILNR or multifocality decreased the mean age by 18 
      and 10 months, respectively, whereas female gender, blastemal/FH or AH increased 
      it by 3, 10, and 16 months. Over 90% of multifocal tumors occurred in the 
      presence of demonstrated ILNR or PLNR or both. The apparent bimodality of the age 
      distributions and later mean ages-at-onset for females with both unifocal and 
      multifocal tumors were explained in part by the relative deficit in females of 
      ILNR versus PLNR-associated tumors. CONCLUSIONS: These observations support the 
      view that there are multiple pathways to Wilms tumorigenesis. They will 
      facilitate selection of informative subgroups of patients for molecular analysis 
      that may serve to identify the putative pathway for the majority of patients who 
      cannot be classified provisionally on the basis of ILNR or PLNR.
FAU - Breslow, Norman E
AU  - Breslow NE
AD  - Department of Biostatistics, University of Washington, Seattle, Washington 
      98195-7232, USA. norm@u.washington.edu
FAU - Beckwith, J Bruce
AU  - Beckwith JB
FAU - Perlman, Elizabeth J
AU  - Perlman EJ
FAU - Reeve, Anthony E
AU  - Reeve AE
LA  - eng
GR  - R01 CA054498/CA/NCI NIH HHS/United States
GR  - R01 CA54998/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
CIN - Pediatr Blood Cancer. 2006 Sep;47(3):232-4. PMID: 16830319
MH  - Age Distribution
MH  - Age of Onset
MH  - Birth Weight
MH  - Child, Preschool
MH  - Female
MH  - Genetic Heterogeneity
MH  - Humans
MH  - Infant
MH  - Kidney Neoplasms/diagnosis/*genetics/*pathology
MH  - Male
MH  - Prognosis
MH  - Wilms Tumor/diagnosis/*genetics/*pathology
PMC - PMC1543666
MID - NIHMS10538
EDAT- 2006/05/16 09:00
MHDA- 2007/01/11 09:00
PMCR- 2008/01/28
CRDT- 2006/05/16 09:00
PHST- 2006/05/16 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/05/16 09:00 [entrez]
PHST- 2008/01/28 00:00 [pmc-release]
AID - 10.1002/pbc.20891 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2006 Sep;47(3):260-7. doi: 10.1002/pbc.20891.