PMID- 16700901
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070727
LR  - 20200929
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 3
DP  - 2006 May 15
TI  - Physiogenomic analysis of weight loss induced by dietary carbohydrate 
      restriction.
PG  - 20
AB  - BACKGROUND: Diets that restrict carbohydrate (CHO) have proven to be a successful 
      dietary treatment of obesity for many people, but the degree of weight loss 
      varies across individuals. The extent to which genetic factors associate with the 
      magnitude of weight loss induced by CHO restriction is unknown. We examined 
      associations among polymorphisms in candidate genes and weight loss in order to 
      understand the physiological factors influencing body weight responses to CHO 
      restriction. METHODS: We screened for genetic associations with weight loss in 86 
      healthy adults who were instructed to restrict CHO to a level that induced a 
      small level of ketosis (CHO approximately 10% of total energy). A total of 27 
      single nucleotide polymorphisms (SNPs) were selected from 15 candidate genes 
      involved in fat digestion/metabolism, intracellular glucose metabolism, 
      lipoprotein remodeling, and appetite regulation. Multiple linear regression was 
      used to rank the SNPs according to probability of association, and the most 
      significant associations were analyzed in greater detail. RESULTS: Mean weight 
      loss was 6.4 kg. SNPs in the gastric lipase (LIPF), hepatic glycogen synthase 
      (GYS2), cholesteryl ester transfer protein (CETP) and galanin (GAL) genes were 
      significantly associated with weight loss. CONCLUSION: A strong association 
      between weight loss induced by dietary CHO restriction and variability in genes 
      regulating fat digestion, hepatic glucose metabolism, intravascular lipoprotein 
      remodeling, and appetite were detected. These discoveries could provide clues to 
      important physiologic adaptations underlying the body mass response to CHO 
      restriction.
FAU - Ruano, Gualberto
AU  - Ruano G
AD  - Genomas, Inc, 67 Jefferson St, Hartford, CT 06106, USA. g.ruano@genomas.net
FAU - Windemuth, Andreas
AU  - Windemuth A
FAU - Kocherla, Mohan
AU  - Kocherla M
FAU - Holford, Theodore
AU  - Holford T
FAU - Fernandez, Maria Luz
AU  - Fernandez ML
FAU - Forsythe, Cassandra E
AU  - Forsythe CE
FAU - Wood, Richard J
AU  - Wood RJ
FAU - Kraemer, William J
AU  - Kraemer WJ
FAU - Volek, Jeff S
AU  - Volek JS
LA  - eng
PT  - Journal Article
DEP - 20060515
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC1479825
EDAT- 2006/05/17 09:00
MHDA- 2006/05/17 09:01
PMCR- 2006/05/15
CRDT- 2006/05/17 09:00
PHST- 2006/03/06 00:00 [received]
PHST- 2006/05/15 00:00 [accepted]
PHST- 2006/05/17 09:00 [pubmed]
PHST- 2006/05/17 09:01 [medline]
PHST- 2006/05/17 09:00 [entrez]
PHST- 2006/05/15 00:00 [pmc-release]
AID - 1743-7075-3-20 [pii]
AID - 10.1186/1743-7075-3-20 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2006 May 15;3:20. doi: 10.1186/1743-7075-3-20.