PMID- 16701146
OWN - NLM
STAT- MEDLINE
DCOM- 20060811
LR  - 20220330
IS  - 0889-8561 (Print)
IS  - 0889-8561 (Linking)
VI  - 26
IP  - 2
DP  - 2006 May
TI  - Targeting dendritic cells in allergen immunotherapy.
PG  - 307-19, viii
AB  - Allergen immunotherapy is a well-established strategy for treating allergic 
      diseases with the goal of inducing allergen-specific tolerance. Identified 
      mechanisms contributing to the therapeutic effect of immunotherapy include a 
      shift of T helper 2 (Th2)-type immune responses to a modified Th2 immune 
      response, a change of the balance of IgE-producing B cells to the production of 
      IgG subtypes, in addition to increased IL-10 and TGF-beta secretion and 
      activation of the suppressive functions of regulatory T-cells. Dendritic cells 
      (DCs), which as outposts of the immune system are capable of T-cell priming 
      through efficient allergen uptake by IgE receptors expressed on their cell 
      surface. Most of the hypotheses concerning the function of DCs as facilitators of 
      allergen-specific tolerance in allergen immunotherapy remain speculative. 
      Therefore, studies must focus on the functional changes of DCs under 
      immunotherapy to close the gap of knowledge about their exact role. These 
      experimental data should help confirm the hypothesis of DCs as efficient 
      silencers and potential target cells and take advantage of the bivalent character 
      and tolerogenic properties of DCs.
FAU - Novak, Natalija
AU  - Novak N
AD  - Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 
      Bonn, Germany. Natalija.Novak@ukb.uni-bonn.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Immunol Allergy Clin North Am
JT  - Immunology and allergy clinics of North America
JID - 8805635
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/*immunology
MH  - Dendritic Cells/*immunology
MH  - Desensitization, Immunologic/*methods
MH  - Humans
MH  - Hypersensitivity/*immunology/*therapy
RF  - 76
EDAT- 2006/05/17 09:00
MHDA- 2006/08/12 09:00
CRDT- 2006/05/17 09:00
PHST- 2006/05/17 09:00 [pubmed]
PHST- 2006/08/12 09:00 [medline]
PHST- 2006/05/17 09:00 [entrez]
AID - S0889-8561(06)00024-5 [pii]
AID - 10.1016/j.iac.2006.02.010 [doi]
PST - ppublish
SO  - Immunol Allergy Clin North Am. 2006 May;26(2):307-19, viii. doi: 
      10.1016/j.iac.2006.02.010.