PMID- 16702976
OWN - NLM
STAT- MEDLINE
DCOM- 20061031
LR  - 20131121
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 11
IP  - 7
DP  - 2006 Jul
TI  - Specificity and timing of neocortical transcriptome changes in response to BDNF 
      gene ablation during embryogenesis or adulthood.
PG  - 633-48
AB  - Brain-derived neurotrophic factor (BDNF) has been reported to be critical for the 
      development of cortical inhibitory neurons. However, the effect of BDNF on the 
      expression of transcripts whose protein products are involved in gamma amino 
      butric acid (GABA) neurotransmission has not been assessed. In this study, gene 
      expression profiling using oligonucleotide microarrays was performed in 
      prefrontal cortical tissue from mice with inducible deletions of BDNF. Both 
      embryonic and adulthood ablation of BDNF gave rise to many shared transcriptome 
      changes. BDNF appeared to be required to maintain gene expression in the 
      SST-NPY-TAC1 subclass of GABA neurons, although the absence of BDNF did not alter 
      their general phenotype as inhibitory neurons. Furthermore, we observed 
      expression alterations in genes encoding early-immediate genes (ARC, EGR1, EGR2, 
      FOS, DUSP1, DUSP6) and critical cellular signaling systems (CDKN1c, CCND2, 
      CAMK1g, RGS4). These BDNF-dependent gene expression changes may illuminate the 
      biological basis for transcriptome changes observed in certain human brain 
      disorders.
FAU - Glorioso, C
AU  - Glorioso C
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15261, 
      USA.
FAU - Sabatini, M
AU  - Sabatini M
FAU - Unger, T
AU  - Unger T
FAU - Hashimoto, T
AU  - Hashimoto T
FAU - Monteggia, L M
AU  - Monteggia LM
FAU - Lewis, D A
AU  - Lewis DA
FAU - Mirnics, K
AU  - Mirnics K
LA  - eng
GR  - 2 P50 MH45156-14/MH/NIMH NIH HHS/United States
GR  - K02 MH070786/MH/NIMH NIH HHS/United States
GR  - R01 MH067234/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060509
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 51110-01-1 (Somatostatin)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - N12000U13O (Doxycycline)
SB  - IM
MH  - Animals
MH  - Brain Diseases/genetics
MH  - Brain-Derived Neurotrophic Factor/deficiency/genetics/*physiology
MH  - Crosses, Genetic
MH  - Doxycycline/pharmacology
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Developmental/drug effects/*genetics
MH  - Genes, Immediate-Early
MH  - Humans
MH  - Immediate-Early Proteins/biosynthesis
MH  - Interneurons/chemistry/ultrastructure
MH  - Intracellular Signaling Peptides and Proteins/genetics/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Nerve Tissue Proteins/*biosynthesis/genetics
MH  - Neurons/classification/metabolism
MH  - Neuropeptide Y/biosynthesis/genetics
MH  - Oligonucleotide Array Sequence Analysis
MH  - Organ Specificity
MH  - Phenotype
MH  - Prefrontal Cortex/embryology/growth & development/*metabolism
MH  - Recombinant Fusion Proteins/biosynthesis/physiology
MH  - Sequence Deletion
MH  - Somatostatin/biosynthesis/genetics
MH  - Time Factors
MH  - *Transcription, Genetic
MH  - gamma-Aminobutyric Acid/analysis
EDAT- 2006/05/17 09:00
MHDA- 2006/11/01 09:00
CRDT- 2006/05/17 09:00
PHST- 2006/05/17 09:00 [pubmed]
PHST- 2006/11/01 09:00 [medline]
PHST- 2006/05/17 09:00 [entrez]
AID - 4001835 [pii]
AID - 10.1038/sj.mp.4001835 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2006 Jul;11(7):633-48. doi: 10.1038/sj.mp.4001835. Epub 2006 May 
      9.