PMID- 16703290
OWN - NLM
STAT- MEDLINE
DCOM- 20071030
LR  - 20191210
IS  - 1439-099X (Electronic)
IS  - 0179-7158 (Linking)
VI  - 182
IP  - 6
DP  - 2006 Jun
TI  - A dosimetric comparison of IORT techniques in limited-stage breast cancer.
PG  - 342-8
AB  - BACKGROUND AND PURPOSE: For intraoperative radiotherapy (IORT) during 
      breast-conserving treatment four different techniques have been addressed: 
      interstitial brachytherapy, an inflatable balloon with a central high-dose-rate 
      source (MammoSite), a miniature orthovolt system (Intrabeam), and linac-based 
      electron radiotherapy (IOERT). The dosimetric properties of these methods are 
      compared. MATERIAL AND METHODS: Planning target volumes (PTVs) of the same size 
      but of different shapes are assumed, corresponding to the technique's specific 
      situs. Dose distributions for the PTVs and for surrounding tissues are 
      demonstrated by dose-volume histograms and a list of physical parameters. A dose 
      inhomogeneity index (DII) is introduced to describe the deviation of a delivered 
      from the prescribed dose, reaching its minimal value 0 in case of perfect 
      homogeneity. RESULTS: In terms of DII, IOERT reaches the lowest value followed by 
      the MammoSite, the Intrabeam and interstitial implants. The surrounding tissues 
      receive the smallest average dose with IOERT, closely followed by the orthovolt 
      system. CONCLUSION: When comparing simplified geometric figures, IOERT delivers 
      the most homogeneous dose distributions. However, in clinical reality PTVs often 
      present asymmetric shapes instead of ideal geometries. Due to a strictly centric 
      dose fall-off, any system with a round central applicator will have technical 
      limits. During IOERT margin-directed applicator guidance is possible and 
      interstitial brachytherapy allows for polygonal dose shaping. These techniques 
      seem to be superior for asymmetric PTV irradiation.
FAU - Nairz, Olaf
AU  - Nairz O
AD  - Department of Radio-Oncology, Salzburger Landeskliniken and Paracelsus Private 
      Medical University (PMU), Salzburg, Austria.
FAU - Deutschmann, Heinz
AU  - Deutschmann H
FAU - Kopp, Michael
AU  - Kopp M
FAU - Wurstbauer, Karl
AU  - Wurstbauer K
FAU - Kametriser, Gerhard
AU  - Kametriser G
FAU - Fastner, Gerd
AU  - Fastner G
FAU - Merz, Florian
AU  - Merz F
FAU - Reitsamer, Roland
AU  - Reitsamer R
FAU - Menzel, Christian
AU  - Menzel C
FAU - Sedlmayer, Felix
AU  - Sedlmayer F
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - Germany
TA  - Strahlenther Onkol
JT  - Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et 
      al]
JID - 8603469
SB  - IM
MH  - Breast Neoplasms/*radiotherapy/*surgery
MH  - Humans
MH  - Intraoperative Care/*methods
MH  - Mastectomy, Segmental/*methods
MH  - Radiometry/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Conformal
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
EDAT- 2006/05/17 09:00
MHDA- 2007/10/31 09:00
CRDT- 2006/05/17 09:00
PHST- 2006/03/15 00:00 [received]
PHST- 2006/03/20 00:00 [accepted]
PHST- 2006/05/17 09:00 [pubmed]
PHST- 2007/10/31 09:00 [medline]
PHST- 2006/05/17 09:00 [entrez]
AID - 10.1007/s00066-006-1580-2 [doi]
PST - ppublish
SO  - Strahlenther Onkol. 2006 Jun;182(6):342-8. doi: 10.1007/s00066-006-1580-2.