PMID- 16706113
OWN - NLM
STAT- MEDLINE
DCOM- 20061013
LR  - 20101118
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 31
IP  - 2
DP  - 2006 Apr
TI  - [Effect of polygonum multiflorum thunb on BDNF expression in rat hippocampus 
      induced by amyloid beta-protein (Abeta) 1-40].
PG  - 194-9
AB  - OBJECTIVE: To explore the effect of polygonum multiflorum thunb (PMT) on the 
      expression of brain-drived neurtrophic factor (BDNF) in hippocampus CA1 in rats 
      induced by Abeta1-40. METHODS: The rat model was established by injecting 
      Abeta1-40 into the right dorsal hippocampus in rats, and their behavior was 
      observed by Y-maze. The morphological changes of rat hippocampus were examined by 
      the Nissl staining. The expression of BDNF in hippocampus CA1 neurons was also 
      examined by immunohistochemistry and Western blot. RESULTS: After the 
      administration of Abeta1-40, the times of rats learning how to elude electric 
      stimulation were significantly increased, and the expression of BDNF in 
      hippocampus CA1 were obviously reduced. The aggregation of Abeta1-40 in 
      hippocampus and the morphological changes of CA1 hippocampus were found. After 
      the treatment with PMT for 30 days, the times learning how to elude electric 
      stimulation were obviously reduced, while the expression of BDNF in hippocampus 
      CA1 was also increased. CONCLUSION: PMT can reverse the down-regulation of BDNF 
      expression in hippocampus CA1 induced by Abeta1-40.
FAU - Qiu, Guang
AU  - Qiu G
AD  - Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South 
      University, Changsha, China.
FAU - Wu, Xiao-qiong
AU  - Wu XQ
FAU - Luo, Xue-gang
AU  - Luo XG
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-40))
SB  - IM
MH  - Amyloid beta-Peptides/*pharmacology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Hippocampus/*metabolism
MH  - Learning/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/drug effects
MH  - Neurons/metabolism
MH  - Peptide Fragments/*pharmacology
MH  - *Polygonum
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2006/05/19 09:00
MHDA- 2006/10/14 09:00
CRDT- 2006/05/19 09:00
PHST- 2006/05/19 09:00 [pubmed]
PHST- 2006/10/14 09:00 [medline]
PHST- 2006/05/19 09:00 [entrez]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Apr;31(2):194-9.