PMID- 16706685
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20191110
IS  - 1744-7631 (Electronic)
IS  - 1472-8222 (Linking)
VI  - 10
IP  - 3
DP  - 2006 Jun
TI  - STAT3: a potential therapeutic target in dendritic cells for the induction of 
      transplant tolerance.
PG  - 459-70
AB  - Dendritic cells (DCs) control the segue from innate to adaptive immunity. 
      Moreover, depending upon their milieu, DCs can either induce or inhibit immune 
      responses. Whether DCs are immune stimulatory or tolerogenic apparently rests 
      with whether or not the DCs express activated signal transducer and activator of 
      transcription-3 (STAT3), the transcription factor induced by IL-6-like cytokines 
      and IL-10. DCs expressing activated STAT3 produce less IL-12, which results in 
      less effector T cell development. Moreover, DCs expressing activated STAT3 also 
      express the tryptophan-catabolising enzyme indoleamine 2,3-dioxygenase. The 
      kynurenine products of tryptophan catabolism induce T cell apoptosis; this area 
      is of major interest to researchers working on tolerogenic DCs. In various 
      disease models ranging from tumours to autoimmune diseases, administration of 
      STAT3-activating cytokines resulted in attenuation of immune responses. Other 
      corroborating evidence was obtained using conditional STAT3-deficient mice, or 
      mice defective in cytokine signalling. Thus, persistently activating STAT3 in DCs 
      may be a feasible strategy for controlling allograft rejection.
FAU - Barton, Beverly E
AU  - Barton BE
AD  - Division of Urology, Department of Surgery, University of Medicine & Dentistry of 
      New Jersey, New Jersey Medical School, Newark, NJ 07103, USA. bartonbe@umdnj.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Ther Targets
JT  - Expert opinion on therapeutic targets
JID - 101127833
RN  - 0 (STAT3 Transcription Factor)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/drug effects/*immunology/metabolism
MH  - Drug Delivery Systems/*methods
MH  - Enzyme Activation/drug effects/immunology
MH  - Humans
MH  - Immune Tolerance/drug effects
MH  - STAT3 Transcription Factor/biosynthesis/*physiology
MH  - Tissue Transplantation/methods
MH  - Transplantation Tolerance/drug effects/*immunology
RF  - 110
EDAT- 2006/05/19 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/05/19 09:00
PHST- 2006/05/19 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/05/19 09:00 [entrez]
AID - 10.1517/14728222.10.3.459 [doi]
PST - ppublish
SO  - Expert Opin Ther Targets. 2006 Jun;10(3):459-70. doi: 10.1517/14728222.10.3.459.