PMID- 16707719
OWN - NLM
STAT- MEDLINE
DCOM- 20061108
LR  - 20220309
IS  - 0022-3077 (Print)
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Linking)
VI  - 96
IP  - 2
DP  - 2006 Aug
TI  - Restoration of long-term potentiation in middle-aged hippocampus after induction 
      of brain-derived neurotrophic factor.
PG  - 677-85
AB  - Restoration of neuronal viability and synaptic plasticity through increased 
      trophic support is widely regarded as a potential therapy for the cognitive 
      declines that characterize aging. Previous studies have shown that in the 
      hippocampal CA1 basal dendritic field deficits in the stabilization of long-term 
      potentiation (LTP) are evident by middle age. The present study tested whether 
      increasing endogenous brain-derived neurotrophic factor (BDNF) could reverse this 
      age-related change. We report here that in middle-aged (8- to 10-mo-old) rats, in 
      vivo treatments with a positive AMPA-type glutamate receptor modulator both 
      increase BDNF protein levels in the cortical telencephalon and restore 
      stabilization of basal dendritic LTP as assessed in acute hippocampal slices 18 h 
      after the last drug treatment. These effects were not attributed to enhanced 
      synaptic transmission or to facilitation of burst responses used to induce LTP. 
      Increasing extracellular levels of BDNF by exogenous application to slices of 
      middle-aged rats was also sufficient to rescue the stabilization of basal 
      dendritic LTP. Finally, otherwise stable LTP in ampakine-treated middle-aged rats 
      can be eliminated by infusion of the extracellular BDNF scavenger TrkB-Fc. 
      Together these results indicate that increases in endogenous BDNF signaling can 
      offset deficits in the postinduction processes that stabilize LTP.
FAU - Rex, Christopher S
AU  - Rex CS
AD  - Department of Neurobiology and Behavior, University of California at Irvine, 
      92697-4292, USA.
FAU - Lauterborn, Julie C
AU  - Lauterborn JC
FAU - Lin, Ching-Yi
AU  - Lin CY
FAU - Kramar, Eniko A
AU  - Kramar EA
FAU - Rogers, Gary A
AU  - Rogers GA
FAU - Gall, Christine M
AU  - Gall CM
FAU - Lynch, Gary
AU  - Lynch G
LA  - eng
GR  - T32 MH014599/MH/NIMH NIH HHS/United States
GR  - R01 NS051823/NS/NINDS NIH HHS/United States
GR  - P01 AG000538/AG/NIA NIH HHS/United States
GR  - AG-00358/AG/NIA NIH HHS/United States
GR  - P01 NS045260/NS/NINDS NIH HHS/United States
GR  - NS-45260/NS/NINDS NIH HHS/United States
GR  - NS-051823/NS/NINDS NIH HHS/United States
GR  - 5-T32-MH-14599-27/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060517
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, AMPA)
SB  - IM
MH  - Aging/*psychology
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Electroencephalography
MH  - Electrophysiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Excitatory Postsynaptic Potentials/drug effects/physiology
MH  - Hippocampus/*physiology
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Prosencephalon/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, AMPA/*drug effects
MH  - Synaptic Transmission/drug effects
MH  - Telencephalon/drug effects/metabolism
PMC - PMC1554892
MID - NIHMS11590
EDAT- 2006/05/19 09:00
MHDA- 2006/11/10 09:00
PMCR- 2008/01/28
CRDT- 2006/05/19 09:00
PHST- 2006/05/19 09:00 [pubmed]
PHST- 2006/11/10 09:00 [medline]
PHST- 2006/05/19 09:00 [entrez]
PHST- 2008/01/28 00:00 [pmc-release]
AID - 00336.2006 [pii]
AID - 10.1152/jn.00336.2006 [doi]
PST - ppublish
SO  - J Neurophysiol. 2006 Aug;96(2):677-85. doi: 10.1152/jn.00336.2006. Epub 2006 May 
      17.