PMID- 16709030
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20060519
IS  - 1092-0684 (Electronic)
IS  - 1092-0684 (Linking)
VI  - 20
IP  - 4
DP  - 2006 Apr 15
TI  - Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic 
      measures.
PG  - E24
AB  - In this article, the author provides a brief description of the role of hypoxia 
      in the tumorigenesis of gliomas and suggests potential ways of exploiting this 
      role to design treatment modalities. Tumor hypoxia predicts the likelihood of 
      metastases, tumor recurrence, resistance to chemotherapy and radiation therapy, 
      invasive potential, and decreased patient survival for many human malignancies. 
      Various methods of measurement of tumor hypoxia are discussed, including direct 
      measurement and imaging methods. The role of hypoxia-responsive molecules, 
      especially hypoxia-inducible factor-1 (HIF-1), in glioma tumorigenesis is 
      explored. Treatment modalities regulated by hypoxia are proposed and some 
      potential strategies reviewed. The progression of a low-grade astrocytoma to a 
      glioblastoma multiforme may be mediated by hypoxia-induced phenotypic changes and 
      subsequent clonal selection of cells that overexpress hypoxia-responsive 
      molecules, such as HIF-1. In this model, intratumoral hypoxia causes genetic 
      changes that produce a microenvironment that selects for cells of a more 
      aggressive phenotype.
FAU - Jensen, Randy L
AU  - Jensen RL
AD  - Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA. 
      randy.jensen@hsc.utah.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060415
PL  - United States
TA  - Neurosurg Focus
JT  - Neurosurgical focus
JID - 100896471
RN  - 0 (Antineoplastic Agents)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Brain Neoplasms/blood supply/drug therapy/*metabolism
MH  - Cell Hypoxia/drug effects
MH  - Cell Transformation, Neoplastic/drug effects/genetics/*metabolism
MH  - Drug Design
MH  - Drug Resistance, Neoplasm/drug effects
MH  - Gene Expression Regulation, Neoplastic
MH  - Glioma/blood supply/drug therapy/*metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/drug effects/genetics/*metabolism
MH  - Neovascularization, Pathologic
RF  - 166
EDAT- 2006/05/20 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/05/20 09:00
PHST- 2006/05/20 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/05/20 09:00 [entrez]
AID - 200424 [pii]
AID - 10.3171/foc.2006.20.4.16 [doi]
PST - epublish
SO  - Neurosurg Focus. 2006 Apr 15;20(4):E24. doi: 10.3171/foc.2006.20.4.16.