PMID- 16709157
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20131121
IS  - 0300-5127 (Print)
IS  - 0300-5127 (Linking)
VI  - 34
IP  - Pt 3
DP  - 2006 Jun
TI  - MLN64 and MENTHO, two mediators of endosomal cholesterol transport.
PG  - 343-5
AB  - MLN64 (metastatic lymph node 64) and MENTHO (MLN64 N-terminal homologue) are two 
      late-endosomal proteins that share a conserved region of four transmembrane 
      helices with three short intervening loops called the MENTAL domain (MLN64 
      N-terminal domain). This domain mediates MLN64 and MENTHO homo- and 
      hetero-interactions, targets both proteins to late endosomes and binds 
      cholesterol in vivo. In addition to the MENTAL domain, MLN64 contains a 
      cholesterol-specific START domain [StAR (steroidogenic acute regulatory 
      protein)-related lipid transfer domain]. The START domain is a protein module of 
      approx. 210 residues that binds lipids, including sterols, and is present in 15 
      distinct proteins in mammals. Thus MLN64 and MENTHO define discrete 
      cholesterol-containing subdomains within the membrane of late endosomes where 
      they may function in cholesterol transport. The MENTAL domain might serve to 
      maintain cholesterol at the membrane of late endosomes prior to its shuttle to 
      cytoplasmic acceptor(s) through the START domain.
FAU - Alpy, F
AU  - Alpy F
AD  - IGBMC (Institut de Genetique et de Biologie Moleculaire et Cellulaire), 
      Departement de Pathologie Moleculaire, UMR7104-CNRS/U596-INSERM/Universite Louis 
      Pasteur, Illkirch, CU de Strasbourg, France.
FAU - Tomasetto, C
AU  - Tomasetto C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (STARD3 protein, human)
RN  - 0 (STARD3NL protein, human)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Biological Transport, Active
MH  - Carrier Proteins/*chemistry/metabolism/*physiology
MH  - Cholesterol/*chemistry/metabolism/physiology
MH  - Endosomes/*chemistry/metabolism/physiology
MH  - Humans
MH  - Membrane Proteins/*chemistry/metabolism/*physiology
RF  - 34
EDAT- 2006/05/20 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/05/20 09:00
PHST- 2006/05/20 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/05/20 09:00 [entrez]
AID - BST0340343 [pii]
AID - 10.1042/BST0340343 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2006 Jun;34(Pt 3):343-5. doi: 10.1042/BST0340343.