PMID- 16710717
OWN - NLM
STAT- MEDLINE
DCOM- 20070202
LR  - 20221207
IS  - 0939-5555 (Print)
IS  - 0939-5555 (Linking)
VI  - 85
IP  - 8
DP  - 2006 Aug
TI  - HLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood 
      ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 signifies a higher presentation 
      leukocytosis: A retrospective analysis on 53 transplant candidates (1989-2003).
PG  - 535-41
AB  - We performed a retrospective analysis on the human leukocyte antigen (HLA) data 
      of 53 consecutive Chinese patients with high-risk childhood acute lymphoblastic 
      leukemia (ALL) diagnosed from 1989 to 2003. A significantly higher frequency of 
      HLA-B67 in the male relapse group of patients [OR, 23.08; 95% CI, 5.31-100.36; p 
      = 0.0042; for statistical significance after Bonferroni correction (Bc) p (Bc) < 
      0.0083] was identified after Bonferroni correction. Although not surviving the 
      Bonferroni correction, gender effects on the association were also observed with 
      HLA-A11, HLA-A32, HLA-A33, and HLA-B22, which were however more prevalent in the 
      female patients and particularly those developing relapse. Two patients with 
      HLA-A29 and HLA-B7 revealed significantly shortened survivals, suggestive of 
      their potential prognostic impacts. Notably, for the first time, we found a 
      significant correlation of leukocyte count with HLA types, where HLA-A33 (p = 
      0.006) or HLA-B17 (p < 0.001) signifies higher leukocytosis at presentation. 
      Taken together, our findings support the involvement of HLA in Chinese high-risk 
      childhood ALL.
FAU - Ng, Margaret H L
AU  - Ng MH
AD  - Hematology Section, Department of Anatomical & Cellular Pathology, The Chinese 
      University of Hong Kong, Prince of Wales Hospital, Shatin, NT, People's Republic 
      of China. margaretng@cuhk.edu.hk
FAU - Lau, K M
AU  - Lau KM
FAU - Hawkins, B R
AU  - Hawkins BR
FAU - Chik, K W
AU  - Chik KW
FAU - Chan, Natalie P H
AU  - Chan NP
FAU - Wong, W S
AU  - Wong WS
FAU - Tsang, K S
AU  - Tsang KS
FAU - Shing, Matthew M K
AU  - Shing MM
FAU - Li, C K
AU  - Li CK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060519
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*33 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B17 antigen)
RN  - 0 (HLA-B67 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People
MH  - Biomarkers, Tumor/*blood
MH  - Child
MH  - Child, Preschool
MH  - Disease Susceptibility/*blood
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - HLA-A Antigens/*blood
MH  - HLA-B Antigens/*blood
MH  - Hong Kong
MH  - Humans
MH  - Leukocytosis/blood/diagnosis/mortality
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*blood/diagnosis/mortality
MH  - Prognosis
MH  - Recurrence
MH  - Retrospective Studies
MH  - Sex Characteristics
EDAT- 2006/05/20 09:00
MHDA- 2007/02/03 09:00
CRDT- 2006/05/20 09:00
PHST- 2005/12/27 00:00 [received]
PHST- 2006/04/03 00:00 [accepted]
PHST- 2006/05/20 09:00 [pubmed]
PHST- 2007/02/03 09:00 [medline]
PHST- 2006/05/20 09:00 [entrez]
AID - 10.1007/s00277-006-0118-0 [doi]
PST - ppublish
SO  - Ann Hematol. 2006 Aug;85(8):535-41. doi: 10.1007/s00277-006-0118-0. Epub 2006 May 
      19.