PMID- 16711428
OWN - NLM
STAT- MEDLINE
DCOM- 20061006
LR  - 20131121
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 31
IP  - 5
DP  - 2006 Mar
TI  - [Effects of Zhikeping on aortic oxyradical and the expression of ICAM-1 in a rat 
      model of experimental early atherosclerosis].
PG  - 407-10
AB  - OBJECTIVE: To investigate the effects of Zhikepingon the oxyradical 
      andintercellular adhesion molecule-1 (ICAM-1) of experimental early 
      atherosclerosis. METHOD: The model of SD rat early atherosclerosis was induced by 
      cholesterol diet. The suspension of Zhikeping and simvastatin were administered 
      intragastrically, respectively. After 10 weeks, the serum lipids, superoxide 
      dismutase (SOD) and maleic dialdehyde (MDA) were detected by automatic 
      biochemistry analyzer. ICAM-1 and its expression of mRNA in aortic wall were 
      detected- by immunohistochemistry and RT-PCR, respectively. Aortic 
      histomorphology was cbserved by HE stainning. RESULT: The results showed that the 
      serum lipids, superoxide dismutase (SOD) and maleic dialdehyde (MDA) of treated 
      groups were obviously improved as compared with those of the control group. The 
      tissue pathological damage was improved indifferent degree, and ICAM-1 and its 
      expression of mRNA was decreased obviously. CONCLUSION: It is suggested the 
      mechanism of anti-atherosclerosis of Zhikeping have close relationship with the 
      function of its anti-oxidizing and anti-adhesiveness that can protect aortic 
      endothelial cell.
FAU - Ding, Qi-feng
AU  - Ding QF
AD  - Institute of Integration of Hebei Medical University, Shijiazhuang, China.
FAU - Chen, Zhi-qiang
AU  - Chen ZQ
FAU - Yin, Zhi-wei
AU  - Yin ZW
FAU - Zhang, Xiu-jun
AU  - Zhang XJ
FAU - Huang, Huai-peng
AU  - Huang HP
FAU - Li, Hong-xia
AU  - Li HX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Lipids)
RN  - 0 (RNA, Messenger)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Aorta/metabolism
MH  - Atherosclerosis/*metabolism/pathology
MH  - Curcuma/chemistry
MH  - Curcumin/isolation & purification/*pharmacology
MH  - Intercellular Adhesion Molecule-1/*biosynthesis/genetics
MH  - Lipids/blood
MH  - Male
MH  - Malondialdehyde/blood
MH  - Plants, Medicinal/chemistry
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Superoxide Dismutase/blood
EDAT- 2006/05/23 09:00
MHDA- 2006/10/07 09:00
CRDT- 2006/05/23 09:00
PHST- 2006/05/23 09:00 [pubmed]
PHST- 2006/10/07 09:00 [medline]
PHST- 2006/05/23 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2006 Mar;31(5):407-10.