PMID- 16712610
OWN - NLM
STAT- MEDLINE
DCOM- 20061109
LR  - 20131121
IS  - 1397-3142 (Print)
IS  - 1397-3142 (Linking)
VI  - 10
IP  - 4
DP  - 2006 Jun
TI  - Unrelated donor cord blood transplantation for childhood severe aplastic anemia 
      after a modified conditioning.
PG  - 497-500
AB  - Treatment of severe aplastic anemia (SAA) patients who lack human leukocyte 
      antigen (HLA)-matched donors and failed immunosuppressive therapy (IST) is 
      challenging. Recently, umbilical cord blood transplantation (CBT) after 
      non-myeloablative therapy has been reported in adult but not in childhood SAA. 
      However, most cases resulted in mixed donor chimerism and incomplete 
      hematological recovery. We reported an 11-yr-old girl with recurred SAA 5 yr 
      after IST who underwent unrelated donor CBT after a modified regimen. This 
      patient had renal and cardiac dysfunction, and lacked suitable bone marrow 
      donors. The 3.9 x 10(7)/kg CB cells from an HLA one-locus mismatched unrelated 
      donor were infused after conditioning with total body irradiation (5 Gy), 
      melphalan (120 mg/m(2)), and fludarabin (120 mg/m(2)). Hematological recovery was 
      favorable in complete chimerism. A major complication was only skin 
      graft-versus-host disease (grade I). CB could be an alternate stem cell source 
      for childhood SAA after modified preparative regimen.
FAU - Ohga, Shouichi
AU  - Ohga S
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka, Japan. ohgas@pediatr.med.kyushu-u.ac.jp
FAU - Ichino, Kiyomi
AU  - Ichino K
FAU - Goto, Kazuna
AU  - Goto K
FAU - Hattori, Sagano
AU  - Hattori S
FAU - Nomura, Akihiko
AU  - Nomura A
FAU - Takada, Hidetoshi
AU  - Takada H
FAU - Nakamura, Katsumasa
AU  - Nakamura K
FAU - Hara, Toshiro
AU  - Hara T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
RN  - 0 (Glucocorticoids)
RN  - 0 (Myeloablative Agonists)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - FA2DM6879K (Vidarabine)
RN  - Q41OR9510P (Melphalan)
SB  - IM
MH  - Anemia, Aplastic/*therapy
MH  - Child
MH  - *Cord Blood Stem Cell Transplantation/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Glucocorticoids/administration & dosage
MH  - Graft vs Host Disease/drug therapy
MH  - *Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - Melphalan/administration & dosage
MH  - Myeloablative Agonists/administration & dosage
MH  - Prednisolone/administration & dosage
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Transplantation Chimera
MH  - *Transplantation Conditioning
MH  - Treatment Outcome
MH  - Vidarabine/administration & dosage/analogs & derivatives
MH  - Whole-Body Irradiation/methods
EDAT- 2006/05/23 09:00
MHDA- 2006/11/11 09:00
CRDT- 2006/05/23 09:00
PHST- 2006/05/23 09:00 [pubmed]
PHST- 2006/11/11 09:00 [medline]
PHST- 2006/05/23 09:00 [entrez]
AID - PTR486 [pii]
AID - 10.1111/j.1399-3046.2006.00486.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2006 Jun;10(4):497-500. doi: 
      10.1111/j.1399-3046.2006.00486.x.