PMID- 16712646
OWN - NLM
STAT- MEDLINE
DCOM- 20060810
LR  - 20221207
IS  - 1744-3121 (Print)
IS  - 1744-3121 (Linking)
VI  - 33
IP  - 3
DP  - 2006 Jun
TI  - Inhibitory and activatory KIR gene frequencies in the Polish population.
PG  - 167-70
AB  - Killer cell immunoglobulin-like receptors (KIRs) present on natural killer cells 
      and minor subpopulations of T cells recognize class I human leukocyte antigen 
      (HLA) molecules on the surface of target cells. Human individuals differ by the 
      presence or absence of some KIR genes on their chromosomes (haplotypic 
      polymorphism). As KIRs (especially two-immunoglobulin-domain-like containing, or 
      KIR2D, molecules) are important for the outcome of tissue (particularly for 
      haematopoietic stem cell) transplantation and possibly for pregnancy, the 
      knowledge of KIR gene distribution in a given human population is of practical 
      value. Therefore, we tested 175 healthy individuals from Poland for the presence 
      or absence of these KIR genes which show haplotypic polymorphism and are 
      expressed. Results were compared with those published for other human 
      populations, showing close relations with other Caucasoids.
FAU - Luszczek, W
AU  - Luszczek W
AD  - Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld 
      Institute, Polish Academy of Sciences, Wroclaw, Poland.
FAU - Majorczyk, E
AU  - Majorczyk E
FAU - Nowak, I
AU  - Nowak I
FAU - Pawlik, A
AU  - Pawlik A
FAU - Jasek, M
AU  - Jasek M
FAU - Wisniewski, A
AU  - Wisniewski A
FAU - Kusnierczyk, P
AU  - Kusnierczyk P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Chromosomes, Human/*genetics/immunology
MH  - Female
MH  - Gene Frequency/*genetics/immunology
MH  - Haplotypes/genetics
MH  - Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Antigens Class I/genetics/immunology
MH  - Humans
MH  - Male
MH  - Poland
MH  - *Polymorphism, Genetic/immunology
MH  - Pregnancy/genetics/immunology
MH  - Pregnancy Outcome/genetics
MH  - Receptors, Immunologic/*genetics/immunology
MH  - Receptors, KIR
MH  - White People
EDAT- 2006/05/23 09:00
MHDA- 2006/08/11 09:00
CRDT- 2006/05/23 09:00
PHST- 2006/05/23 09:00 [pubmed]
PHST- 2006/08/11 09:00 [medline]
PHST- 2006/05/23 09:00 [entrez]
AID - EJI587 [pii]
AID - 10.1111/j.1744-313X.2006.00587.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2006 Jun;33(3):167-70. doi: 10.1111/j.1744-313X.2006.00587.x.