PMID- 16713232
OWN - NLM
STAT- MEDLINE
DCOM- 20070308
LR  - 20070112
IS  - 0955-2863 (Print)
IS  - 0955-2863 (Linking)
VI  - 18
IP  - 2
DP  - 2007 Feb
TI  - Caloric restriction inhibits up-regulation of inflammatory cytokines and 
      TNF-alpha, and activates IL-10 and haptoglobin in the plasma of 
      streptozotocin-induced diabetic rats.
PG  - 120-6
AB  - Diabetes mellitus is a significant risk factor for cardiovascular diseases, and 
      low-grade systemic inflammation, mediated by oxidative stress, may play a central 
      role. Caloric restriction (CR) has been reported to be effective in reducing 
      oxidative stress during diabetes and moderating the expression of some markers of 
      inflammation that are up-regulated during aging. Forty male Wistar rats were 
      randomly divided into four groups: nondiabetic feeding ad libitum and under CR, 
      and diabetic feeding ad libitum and under CR. The animals were subjected to 30% 
      CR and ad libitum feeding for 9 weeks before the induction of diabetes by 
      intraperitoneal injection with 35 mg/kg body weight streptozotocin. The 
      inflammatory cytokines [interleukin (IL)-1beta, IL-4 and IL-6] and tumor necrosis 
      factor alpha up-regulated in diabetes were found to be significantly depressed by 
      CR, whereas the antiinflammatory mediators, haptoglobin and IL-10 levels, were 
      increased. These results indicated that CR could prevent diabetic complications 
      through suppression of inflammatory responses.
FAU - Ugochukwu, Ngozi H
AU  - Ugochukwu NH
AD  - Department of Chemistry, Florida A&M University, Tallahassee, FL 32307, USA. 
      ngozi.ugochukwu@famu.edu
FAU - Figgers, Cynthia L
AU  - Figgers CL
LA  - eng
PT  - Journal Article
DEP - 20060518
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Haptoglobins)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Cytokines/*blood
MH  - Diabetes Mellitus, Experimental/*blood
MH  - Haptoglobins/*analysis
MH  - Inflammation/*blood
MH  - Interleukin-10/blood
MH  - Interleukin-1beta/blood
MH  - Interleukin-4/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2006/05/23 09:00
MHDA- 2007/03/09 09:00
CRDT- 2006/05/23 09:00
PHST- 2006/01/11 00:00 [received]
PHST- 2006/03/05 00:00 [revised]
PHST- 2006/03/23 00:00 [accepted]
PHST- 2006/05/23 09:00 [pubmed]
PHST- 2007/03/09 09:00 [medline]
PHST- 2006/05/23 09:00 [entrez]
AID - S0955-2863(06)00078-7 [pii]
AID - 10.1016/j.jnutbio.2006.03.008 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2007 Feb;18(2):120-6. doi: 10.1016/j.jnutbio.2006.03.008. Epub 
      2006 May 18.