PMID- 16713371
OWN - NLM
STAT- MEDLINE
DCOM- 20061220
LR  - 20091119
IS  - 1567-133X (Print)
IS  - 1567-133X (Linking)
VI  - 6
IP  - 8
DP  - 2006 Oct
TI  - BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the 
      human lifespan.
PG  - 941-51
AB  - Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B 
      (trkB) influence neuronal survival, differentiation, synaptogenesis, and 
      maintenance. Using in situ hybridization we examined the spatial and temporal 
      expression of mRNAs encoding these proteins during diverse stages of life in the 
      human hippocampus and inferior temporal cortex. We examined six postnatal time 
      points: neonatal (1-3 months), infant (4-12 months), adolescent (14-18 years), 
      young adult (20-24 years), adult (34-43 years), and aged (68-86 years). Within 
      the hippocampus, levels of BDNF mRNA did not change significantly with age. 
      However, levels of both the full-length form of trkB (trkB TK+) mRNA and the 
      truncated form of trkB (trkB TK-) decreased over the life span (p < 0.05). In the 
      temporal cortex, BDNF and trkB TK+ mRNA levels were highest in neonates and 
      decreased with age (r = -0.4 and r = -0.7, respectively, both p < 0.05). In 
      contrast, TrkB TK- mRNA levels remained constant across the life span in the 
      temporal cortex. The peak in both BDNF and trkB TK+ mRNA expression in the 
      neonate temporal cortex differs from that previously described for the frontal 
      cortex where both mRNAs peak in expression during young adulthood. The increase 
      in BDNF and trkB TK+ mRNA in the temporal cortex of the neonate suggests that 
      neurotrophin signaling is important in the early development of the temporal 
      cortex. In addition, since BDNF and both forms of its high affinity receptor are 
      expressed throughout the development, maturation, and aging of the human 
      hippocampus and surrounding neocortex they are likely to play roles not only in 
      early growth but also in maintenance of neurons throughout life.
FAU - Webster, M J
AU  - Webster MJ
AD  - Stanley Laboratory of Brain Research, USUHS, Bethesda, MD 20814, USA. 
      websterm@stanleyresearch.org
FAU - Herman, M M
AU  - Herman MM
FAU - Kleinman, J E
AU  - Kleinman JE
FAU - Shannon Weickert, C
AU  - Shannon Weickert C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060330
PL  - Netherlands
TA  - Gene Expr Patterns
JT  - Gene expression patterns : GEP
JID - 101167473
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*metabolism
MH  - Autopsy
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Cortex/anatomy & histology/growth & development/*metabolism
MH  - Female
MH  - Gene Expression Profiling
MH  - Hippocampus/anatomy & histology/growth & development/*metabolism
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - RNA, Messenger/metabolism
MH  - Receptor, trkB/*metabolism
MH  - Temporal Lobe/anatomy & histology/growth & development/*metabolism
MH  - Tissue Distribution
EDAT- 2006/05/23 09:00
MHDA- 2006/12/21 09:00
CRDT- 2006/05/23 09:00
PHST- 2005/11/11 00:00 [received]
PHST- 2006/03/15 00:00 [revised]
PHST- 2006/03/24 00:00 [accepted]
PHST- 2006/05/23 09:00 [pubmed]
PHST- 2006/12/21 09:00 [medline]
PHST- 2006/05/23 09:00 [entrez]
AID - S1567-133X(06)00070-6 [pii]
AID - 10.1016/j.modgep.2006.03.009 [doi]
PST - ppublish
SO  - Gene Expr Patterns. 2006 Oct;6(8):941-51. doi: 10.1016/j.modgep.2006.03.009. Epub 
      2006 Mar 30.