PMID- 16713676
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20151119
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 402
IP  - 1-2
DP  - 2006 Jul 10
TI  - Effects of quetiapine on the brain-derived neurotrophic factor expression in the 
      hippocampus and neocortex of rats.
PG  - 25-9
AB  - The effects of antipsychotics on the brain-derived neurotrophic factor (BDNF) 
      expression have been controversial. This study aimed to investigate the effects 
      of chronic quetiapine administration on the BDNF mRNA expression in hippocampus 
      and neocortex of rats with or without immobilization stress. The chronic 
      administration (21 days) of quetiapine (10 mg/kg) significantly attenuated the 
      decreased BDNF mRNA expression in the both hippocampal and cortical regions of 
      rats caused by immobilization stress, and significantly increased the BDNF mRNA 
      expression in the dentate gyrus of rats even without the immobilization stress. 
      These results could add some theoretical bases to explain why quetiapine may 
      improve cognitive symptoms of schizophrenia by stimulating BDNF mRNA expression.
FAU - Park, Sung-Woo
AU  - Park SW
AD  - Department of Neuropsychiatry, School of Medicine, Paik Inje Memorial Clinical 
      Research Institute, Inje University, Busan, Republic of Korea.
FAU - Lee, Sun-Kyung
AU  - Lee SK
FAU - Kim, Jae-Min
AU  - Kim JM
FAU - Yoon, Jin-Sang
AU  - Yoon JS
FAU - Kim, Young-Hoon
AU  - Kim YH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060519
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dibenzothiazepines)
RN  - 0 (RNA, Messenger)
RN  - 2S3PL1B6UJ (Quetiapine Fumarate)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antipsychotic Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Dibenzothiazepines/*pharmacology
MH  - Gene Expression/*drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/*drug effects
MH  - In Situ Hybridization/methods
MH  - Male
MH  - Neocortex/*drug effects
MH  - Quetiapine Fumarate
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Stress, Physiological/drug therapy/metabolism/pathology
EDAT- 2006/05/23 09:00
MHDA- 2007/01/17 09:00
CRDT- 2006/05/23 09:00
PHST- 2006/01/24 00:00 [received]
PHST- 2006/03/09 00:00 [revised]
PHST- 2006/03/09 00:00 [accepted]
PHST- 2006/05/23 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2006/05/23 09:00 [entrez]
AID - S0304-3940(06)00286-2 [pii]
AID - 10.1016/j.neulet.2006.03.028 [doi]
PST - ppublish
SO  - Neurosci Lett. 2006 Jul 10;402(1-2):25-9. doi: 10.1016/j.neulet.2006.03.028. Epub 
      2006 May 19.