PMID- 16714125
OWN - NLM
STAT- MEDLINE
DCOM- 20061207
LR  - 20191210
IS  - 1074-7427 (Print)
IS  - 1074-7427 (Linking)
VI  - 86
IP  - 3
DP  - 2006 Nov
TI  - Excitotoxic lesions of the parafascicular nucleus produce deficits in a socially 
      transmitted food preference.
PG  - 256-63
AB  - The parafascicular (PF) nucleus, a posterior component of the intralaminar nuclei 
      of the thalamus, is considered to be an essential structure in the feedback 
      circuits of basal ganglia-thalamo-cortical systems that critically participate in 
      cognitive processes. To study the PF contribution to processing of behaviorally 
      significant information during specific episodes of learning, we investigated the 
      effects of damaging the PF nucleus in the acquisition of a natural form of social 
      olfactory learning, the socially transmitted food preference (STFP) task. This 
      task is a non-spatial paradigm that exhibits some of the characteristics of 
      relational memory because it requires that animals use information obtained in 
      one episode to guide later behavior in different circumstances. Adult male Wistar 
      rats were submitted to pretraining bilateral N-methyl-D-aspartate (0.15 M, pH 
      7.4) lesions of the PF (0.4 microl/side, 0.2 microl/min). The behavioral effects 
      of PF lesions were compared to vehicle- and sham-operated control groups and two 
      retention delays were considered in separate groups: immediately (Lesion-I, 
      Vehicle-I, and Sham-I groups) and 24h after training (Lesion-24, Vehicle-24, and 
      Sham-24 groups). PF lesions produced delay-independent impairments in the STFP 
      suggesting that this nucleus might modulate the acquisition of this odor-odor 
      association task. Results are discussed in the context of medial prefrontal 
      cortex deafferentation induced by PF damage.
FAU - Quiroz-Padilla, Maria Fernanda
AU  - Quiroz-Padilla MF
AD  - Departament de Psicobiologia i Metodologia de les Ciencies de la Salut, Institut 
      de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra 
      (Barcelona), Spain.
FAU - Guillazo-Blanch, Gemma
AU  - Guillazo-Blanch G
FAU - Vale-Martinez, Anna
AU  - Vale-Martinez A
FAU - Marti-Nicolovius, Margarita
AU  - Marti-Nicolovius M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060522
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Association Learning/*physiology
MH  - Discrimination Learning/physiology
MH  - Food Preferences/*physiology
MH  - Imitative Behavior/*physiology
MH  - Intralaminar Thalamic Nuclei/*physiology
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Retention, Psychology/physiology
MH  - Smell/physiology
MH  - *Social Environment
MH  - Statistics, Nonparametric
MH  - Time Factors
EDAT- 2006/05/23 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/05/23 09:00
PHST- 2006/01/23 00:00 [received]
PHST- 2006/03/29 00:00 [revised]
PHST- 2006/03/29 00:00 [accepted]
PHST- 2006/05/23 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/05/23 09:00 [entrez]
AID - S1074-7427(06)00050-5 [pii]
AID - 10.1016/j.nlm.2006.03.007 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2006 Nov;86(3):256-63. doi: 10.1016/j.nlm.2006.03.007. Epub 
      2006 May 22.