PMID- 16716341
OWN - NLM
STAT- MEDLINE
DCOM- 20060920
LR  - 20131121
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1124
IP  - 1-2
DP  - 2006 Aug 18
TI  - Extraction and preconcentration of salbutamol and terbutaline from aqueous 
      samples using hollow fiber supported liquid membrane containing anionic carrier.
PG  - 57-67
AB  - This paper presents a new three-phase liquid-phase microextraction (LPME) 
      strategy for extraction and preconcentration of salbutamol (SB) and terbutaline 
      (TB) from aqueous samples, including urine. The drugs were extracted from 11 ml 
      of aqueous sample (source phase; SP) into an organic phase with microliter volume 
      located inside the pores of a polypropylene hollow fiber, and then back-extracted 
      into 24 microl of a second aqueous solution as the receiving phase (RP), located 
      in the lumen of the hollow fiber. In preliminary experiments, we tried to 
      transport the drugs using a pH gradient between the two sides of the hollow 
      fiber. Due to the existence of both amine and phenolic groups on the drugs, very 
      little transport occurred and enrichment factors (EF) less than one were 
      obtained. Further experiments were done in the presence of bis(2-ethylhexyl) 
      monohydrogenphosphoric acid (D2EHPA) or methyltrioctylammonium chloride (Aliquat 
      336) in the organic phase, to extract drugs from acidic and basic matrices, 
      respectively. Results showed that transport of drugs from alkaline solution into 
      1M of sodium bromide occurred when the membrane was impregnated with dihexyl 
      ether containing 20% Aliquat 336. To optimize the EF, the effects of different 
      parameters such as the nature of organic solvent used to impregnate the membrane, 
      compositions and volumes of SP and RP, type and concentration of carrier, 
      extraction time and stirring rate were investigated. Optimal results were 
      obtained in the presence of 0.005 M of NaOH (pH 11.70) in the SP, 1M of NaBr in 
      the RP, 20% of Aliquat 336 in dihexyl ether as membrane impregnation solvent, 
      stirring rate of 500 rpm and extraction time of 60 min. Under these conditions, 
      enrichment factors of 52.9 and 213.1, dynamic linear ranges of 20-5000 and 
      10-5000, and limits of detection of 2.5 and 0.5 ng/ml were obtained for 
      salbutamol and terbutaline, respectively. Also determination of drugs in 
      environmental water and urine samples in the range of nanograms per millilitre 
      with RSDs<10% was possible using HPLC-photodiode array detection or HPLC-MS.
FAU - Yamini, Yadollah
AU  - Yamini Y
AD  - Department of Chemistry, Tarbiat Modarres University, P.O. Box 11415-175, Tehran, 
      Iran.
FAU - Reimann, Curt T
AU  - Reimann CT
FAU - Vatanara, Alireza
AU  - Vatanara A
FAU - Jonsson, Jan Ake
AU  - Jonsson JA
LA  - eng
PT  - Journal Article
DEP - 20060522
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Anions)
RN  - 0 (Membranes, Artificial)
RN  - N8ONU3L3PG (Terbutaline)
RN  - QF8SVZ843E (Albuterol)
SB  - IM
MH  - Albuterol/*isolation & purification
MH  - *Anions
MH  - Chromatography, High Pressure Liquid
MH  - *Membranes, Artificial
MH  - Reference Standards
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Terbutaline/*isolation & purification
EDAT- 2006/05/24 09:00
MHDA- 2006/09/21 09:00
CRDT- 2006/05/24 09:00
PHST- 2006/03/10 00:00 [received]
PHST- 2006/04/29 00:00 [revised]
PHST- 2006/05/01 00:00 [accepted]
PHST- 2006/05/24 09:00 [pubmed]
PHST- 2006/09/21 09:00 [medline]
PHST- 2006/05/24 09:00 [entrez]
AID - S0021-9673(06)00926-5 [pii]
AID - 10.1016/j.chroma.2006.05.001 [doi]
PST - ppublish
SO  - J Chromatogr A. 2006 Aug 18;1124(1-2):57-67. doi: 10.1016/j.chroma.2006.05.001. 
      Epub 2006 May 22.