PMID- 16720211
OWN - NLM
STAT- MEDLINE
DCOM- 20060828
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 4-5
DP  - 2006 Apr-May
TI  - Lack of association of IL-10 promoter gene variants with type 1 diabetes in a 
      French population.
PG  - 311-7
AB  - Although genetic predisposition to type 1 diabetes shows a strong association 
      with human leukocyte antigen (HLA) class II alleles, additional genes may 
      influence the immune process and the progression of beta cell loss. Preliminary 
      reports suggested that IL-10 gene polymorphisms contribute to susceptibility to 
      type 1 diabetes. We analyzed the frequencies of three main variants of the 
      promoter region of the IL-10 gene at the positions -1082, -819, and -592 in a 
      cohort of 358 type 1 diabetic patients representing the same regional population 
      pattern and 519 controls from the same region using an enzyme-linked 
      oligonucleotide sorbent assay. We did not find any statistical association in the 
      entire cohort or after stratification for high-risk HLA-DQ alleles. However, the 
      IL-10 -1082 polymorphism was significantly associated with GAD and IA-2 
      antibodies at clinical onset. Such polymorphism is known to be associated with 
      the reduction of secreted IL-10 which may support the concept of accelerated Th-1 
      T-cell reactivity. In conclusion, IL-10 promoter gene variants may contribute, 
      but to a minor extent, to disease susceptibility in juvenile type 1 diabetes and 
      should not be included in the routine genetic screening of high-risk individuals.
FAU - Reynier, Frederic
AU  - Reynier F
AD  - HCL-bioMerieux Joint Unit, Edouard Herriot Hospital, 69347 Lyon, France.
FAU - Cazalis, Marie-Angelique
AU  - Cazalis MA
FAU - Lecoq, Annick
AU  - Lecoq A
FAU - Paye, Malick
AU  - Paye M
FAU - Rosa, Audrey
AU  - Rosa A
FAU - Durand, Annie
AU  - Durand A
FAU - Jhumka, Umar
AU  - Jhumka U
FAU - Mougin, Bruno
AU  - Mougin B
FAU - Miossec, Pierre
AU  - Miossec P
FAU - Bendelac, Nathalie
AU  - Bendelac N
FAU - Nicolino, Marc
AU  - Nicolino M
FAU - Thivolet, Charles
AU  - Thivolet C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060407
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Autoantibodies)
RN  - 0 (ICA512 autoantibody)
RN  - 130068-27-8 (Interleukin-10)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoantibodies/blood/genetics
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*epidemiology/*genetics
MH  - Female
MH  - France/epidemiology
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Glutamate Decarboxylase/immunology
MH  - Humans
MH  - Infant
MH  - Interleukin-10/*genetics
MH  - Male
MH  - Molecular Epidemiology
MH  - Polymorphism, Genetic
MH  - Population/genetics
MH  - Promoter Regions, Genetic/genetics
MH  - White People/*genetics
EDAT- 2006/05/25 09:00
MHDA- 2006/08/29 09:00
CRDT- 2006/05/25 09:00
PHST- 2005/11/24 00:00 [received]
PHST- 2006/05/25 09:00 [pubmed]
PHST- 2006/08/29 09:00 [medline]
PHST- 2006/05/25 09:00 [entrez]
AID - S0198-8859(06)00017-6 [pii]
AID - 10.1016/j.humimm.2006.02.029 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Apr-May;67(4-5):311-7. doi: 10.1016/j.humimm.2006.02.029. Epub 
      2006 Apr 7.