PMID- 16720214
OWN - NLM
STAT- MEDLINE
DCOM- 20060828
LR  - 20111117
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 4-5
DP  - 2006 Apr-May
TI  - HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and 
      meta-analysis.
PG  - 331-40
AB  - Polymorphisms in human leukocyte antigen (HLA) genes have been implicated in the 
      risk for cervical cancer. Association of certain class II HLA alleles with 
      cervical cancer has been documented in various ethnic populations. The 
      implications of such an association, however, are controversial. We analyzed 126 
      Chinese women with cervical squamous cell carcinoma (CSCC) and 289 healthy 
      controls to test associations of certain HLA-DRB1 alleles. We then performed 
      meta-analyses combining our own experimental data and data from nine other 
      published studies. We found no significant differences in HLA-DRB1 allele 
      frequencies in both CSCC and HPV-16-positive CSCC patients and control subjects. 
      Meta-analysis provided evidence that four allele families (HLA-DRB1*04, *07, *11, 
      and *15) and seven alleles (HLA-DRB1*0403, *0405, *0407, *0701, *1501, *1502, and 
      *1503) were positively associated and two allele families (HLA-DRB1*09 and *13) 
      and four alleles (HLA-DRB1*0901, *1301, *1302, and *1602) were negatively 
      associated with CSCC in all studies or in Caucasian subgroups. In conclusion, our 
      meta-analysis confirms the apparent association between certain HLA-DRB1 allele 
      families and alleles and CSCC, suggesting that oncogenesis in this disease may be 
      related to defects in immunoregulation. Larger studies may be needed, 
      particularly in various ethnic groups, to further substantiate these 
      associations.
FAU - Yang, Yuh-Cheng
AU  - Yang YC
AD  - Department of Gynecology, Mackay Memorial Hospital, Taipei, Taiwan. 
      eugene@ms2.mmh.org.tw
FAU - Chang, Tzu-Yang
AU  - Chang TY
FAU - Lee, Yann-Jinn
AU  - Lee YJ
FAU - Su, Tsung-Hsien
AU  - Su TH
FAU - Dang, Ching-Wen
AU  - Dang CW
FAU - Wu, Chao-Chih
AU  - Wu CC
FAU - Liu, Hsin-Fu
AU  - Liu HF
FAU - Chu, Chen-Chung
AU  - Chu CC
FAU - Lin, Marie
AU  - Lin M
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20060504
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Carcinoma, Squamous Cell/epidemiology/*genetics/immunology
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Uterine Cervical Neoplasms/epidemiology/*genetics/immunology
EDAT- 2006/05/25 09:00
MHDA- 2006/08/29 09:00
CRDT- 2006/05/25 09:00
PHST- 2005/11/04 00:00 [received]
PHST- 2006/05/25 09:00 [pubmed]
PHST- 2006/08/29 09:00 [medline]
PHST- 2006/05/25 09:00 [entrez]
AID - S0198-8859(06)00056-5 [pii]
AID - 10.1016/j.humimm.2006.03.017 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Apr-May;67(4-5):331-40. doi: 10.1016/j.humimm.2006.03.017. Epub 
      2006 May 4.