PMID- 16720216
OWN - NLM
STAT- MEDLINE
DCOM- 20060828
LR  - 20101118
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 4-5
DP  - 2006 Apr-May
TI  - The association and linkage of the HLA-A2 class I allele with autism.
PG  - 346-51
AB  - Previous research has revealed associations between autism and immune genes 
      located in the human leukocyte antigen (HLA). To better understand which HLA 
      genetic loci may be associated with autism, we compared the class I HLA-A and -B 
      alleles in autistic probands with case control subjects from Caucasian families. 
      The frequency of HLA-A2 alleles was significantly increased in autistic subjects 
      compared with normal allelic frequencies from the National Marrow Donors Program 
      (NMDP) (p = 0.0043 after allelic correction). The transmission disequilibrium 
      test for the A2 allele revealed an increased frequency of inheritance for 
      autistic children (p = 0.033). There were no significant associations of autism 
      with HLA-B alleles; however, the A2-B44 and A2-B51 haplotypes were two times more 
      frequent in autistic subjects. The association and linkage of the class I HLA-A2 
      allele with autism suggests its involvement in the etiology of autism. Possible 
      roles are discussed for the HLA-A2 association in the presentation of microbial 
      antigen within the central nervous system and/or in the establishment of synaptic 
      and neuronal circuits in the developing brain.
FAU - Torres, Anthony R
AU  - Torres AR
AD  - Center for Persons with Disabilities, Utah State University, Logan, UT 
      84322-6895, USA. rtorres@cpd2.usu.edu
FAU - Sweeten, Thayne L
AU  - Sweeten TL
FAU - Cutler, Adele
AU  - Cutler A
FAU - Bedke, Brent J
AU  - Bedke BJ
FAU - Fillmore, Melanie
AU  - Fillmore M
FAU - Stubbs, E Gene
AU  - Stubbs EG
FAU - Odell, Dennis
AU  - Odell D
LA  - eng
GR  - 1R03NS51549/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060403
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - Autistic Disorder/*genetics/*immunology
MH  - Genetic Linkage
MH  - HLA-A2 Antigen/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
EDAT- 2006/05/25 09:00
MHDA- 2006/08/29 09:00
CRDT- 2006/05/25 09:00
PHST- 2005/10/07 00:00 [received]
PHST- 2006/01/02 00:00 [revised]
PHST- 2006/01/04 00:00 [accepted]
PHST- 2006/05/25 09:00 [pubmed]
PHST- 2006/08/29 09:00 [medline]
PHST- 2006/05/25 09:00 [entrez]
AID - S0198-8859(06)00042-5 [pii]
AID - 10.1016/j.humimm.2006.01.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Apr-May;67(4-5):346-51. doi: 10.1016/j.humimm.2006.01.001. Epub 
      2006 Apr 3.