PMID- 16720367
OWN - NLM
STAT- MEDLINE
DCOM- 20060627
LR  - 20190902
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 11
DP  - 2006 Sep 1
TI  - Matrix metalloproteinases and their inhibitors in bone: an overview of regulation 
      and functions.
PG  - 2949-66
AB  - Matrix metalloproteinases (MMPs), a family of Zn2+-dependent endopeptidases, 
      mediate different physiological processes by digesting components of the 
      extracellular matrix. Nevertheless, overexpression of MMPs is implicated in the 
      pathogenesis of various diseases. Different MMPs and tissue inhibitors of MMPs 
      (TIMPs) are expressed in bone cells, and their biosynthesis is regulated by local 
      and systemic hormones and factors. The levels of enzymatically active MMPs in 
      bone are further controlled by secretion, activation of proenzymes, inhibition by 
      TIMPs, cellular uptake and degradation. Members of the cysteine and serine family 
      of proteinases also coordinate some of the biological activities of MMPs in bone. 
      The functions of MMPs and TIMPs in bone include regulation of processes, such as 
      degradation of collagen and other components of the bone matrix, migration and 
      survival of bone cells, endochondral bone formation and bone resorption. Abnormal 
      expression of MMPs may lead to pathological conditions affecting bone and 
      cartilage. Various pharmacological agents can inhibit MMPs, and some of these 
      inhibitors may be potential therapeutic agents for certain bone diseases. This 
      review briefly describes the regulation and functions of different MMPs and TIMPs 
      in bone, and provides an insight into the role of MMPs in bone development, 
      remodeling and pathology.
FAU - Varghese, Samuel
AU  - Varghese S
AD  - Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA. 
      svarghes@stfranciscare.org
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060901
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (Diphosphonates)
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - 0 (Tetracyclines)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.4.- (Cathepsins)
RN  - EC 3.4.21.- (Plasminogen Activators)
RN  - EC 3.4.24.- (Collagenases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - *Bone Development
MH  - Bone Diseases/physiopathology
MH  - Bone Remodeling/*physiology
MH  - Cathepsins/metabolism
MH  - Collagen/metabolism
MH  - Collagenases/*metabolism
MH  - Diphosphonates/pharmacology
MH  - Extracellular Matrix/metabolism
MH  - Humans
MH  - *Matrix Metalloproteinase Inhibitors
MH  - Matrix Metalloproteinases/*metabolism
MH  - Plasminogen Activators/metabolism
MH  - Tetracyclines/pharmacology
MH  - Tissue Inhibitor of Metalloproteinases/*physiology
RF  - 236
EDAT- 2006/05/25 09:00
MHDA- 2006/06/28 09:00
CRDT- 2006/05/25 09:00
PHST- 2006/05/25 09:00 [pubmed]
PHST- 2006/06/28 09:00 [medline]
PHST- 2006/05/25 09:00 [entrez]
AID - 2024 [pii]
AID - 10.2741/2024 [doi]
PST - epublish
SO  - Front Biosci. 2006 Sep 1;11:2949-66. doi: 10.2741/2024.