PMID- 16720655
OWN - NLM
STAT- MEDLINE
DCOM- 20060918
LR  - 20161118
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 91
IP  - 8
DP  - 2006 Aug
TI  - Effect of long-term calorie restriction with adequate protein and micronutrients 
      on thyroid hormones.
PG  - 3232-5
AB  - CONTEXT: Caloric restriction (CR) retards aging in mammals. It has been 
      hypothesized that a reduction in T(3) hormone may increase life span by 
      conserving energy and reducing free-radical production. OBJECTIVE: The objective 
      of the study was to assess the relationship between long-term CR with adequate 
      protein and micronutrient intake on thyroid function in healthy lean 
      weight-stable adult men and women. DESIGN, SETTING, AND PARTICIPANTS: In this 
      study, serum thyroid hormones were evaluated in 28 men and women (mean age, 52 
      +/- 12 yr) consuming a CR diet for 3-15 yr (6 +/- 3 yr), 28 age- and sex-matched 
      sedentary (WD), and 28 body fat-matched exercising (EX) subjects who were eating 
      Western diets. MAIN OUTCOME MEASURES: Serum total and free T(4), total and free 
      T(3), reverse T(3), and TSH concentrations were the main outcome measures. 
      RESULTS: Energy intake was lower in the CR group (1779 +/- 355 kcal/d) than the 
      WD (2433 +/- 502 kcal/d) and EX (2811 +/- 711 kcal/d) groups (P < 0.001). Serum 
      T(3) concentration was lower in the CR group than the WD and EX groups (73.6 +/- 
      22 vs. 91.0 +/- 13 vs. 94.3 +/- 17 ng/dl, respectively) (P < or = 0.001), whereas 
      serum total and free T(4), reverse T(3), and TSH concentrations were similar 
      among groups. CONCLUSIONS: Long-term CR with adequate protein and micronutrient 
      intake in lean and weight-stable healthy humans is associated with a sustained 
      reduction in serum T(3) concentration, similar to that found in CR rodents and 
      monkeys. This effect is likely due to CR itself, rather than to a decrease in 
      body fat mass, and could be involved in slowing the rate of aging.
FAU - Fontana, Luigi
AU  - Fontana L
AD  - Washington University School of Medicine, 4566 Scott Avenue, Campus Box 8113, St. 
      Louis, MO 63110, USA. lfontana@im.wustl.edu
FAU - Klein, Samuel
AU  - Klein S
FAU - Holloszy, John O
AU  - Holloszy JO
FAU - Premachandra, Bhartur N
AU  - Premachandra BN
LA  - eng
GR  - DK 20579/DK/NIDDK NIH HHS/United States
GR  - P30 DK056341/DK/NIDDK NIH HHS/United States
GR  - R01 DK 37948/DK/NIDDK NIH HHS/United States
GR  - P30 DK056341-06/DK/NIDDK NIH HHS/United States
GR  - DK 56351/DK/NIDDK NIH HHS/United States
GR  - P30 DK056341-05S2/DK/NIDDK NIH HHS/United States
GR  - M01 RR 00036/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060523
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Dietary Proteins)
RN  - 0 (Micronutrients)
RN  - 0 (Thyroid Hormones)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 5817-39-0 (Triiodothyronine, Reverse)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Body Composition
MH  - Body Mass Index
MH  - *Caloric Restriction
MH  - Dietary Proteins/*administration & dosage
MH  - Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - Micronutrients/*administration & dosage
MH  - Middle Aged
MH  - Nutritional Physiological Phenomena
MH  - Thyroid Hormones/*blood
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
MH  - Triiodothyronine, Reverse/blood
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2006/05/25 09:00
MHDA- 2006/09/19 09:00
CRDT- 2006/05/25 09:00
PHST- 2006/05/25 09:00 [pubmed]
PHST- 2006/09/19 09:00 [medline]
PHST- 2006/05/25 09:00 [entrez]
AID - jc.2006-0328 [pii]
AID - 10.1210/jc.2006-0328 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2006 Aug;91(8):3232-5. doi: 10.1210/jc.2006-0328. Epub 
      2006 May 23.