PMID- 1672224
OWN - NLM
STAT- MEDLINE
DCOM- 19910412
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 48
IP  - 13
DP  - 1991
TI  - Participation of noradrenergic neurotransmission in angiotensin III-induced 
      dipsogenic behavior in the rat.
PG  - 1293-301
AB  - Conscious, adult, male Sprague-Dawley rats, instrumented with in-dwelling cannula 
      for drug application into the lateral cerebral ventricle, were used to evaluate 
      the participation of noradrenergic neurotransmission in angiotensin III 
      (AIII)-induced dipsogenic behavior. Intracerebroventricular (i.c.v.) 
      administration of AIII (20, 40 or 80 pmol) elicited a robust and dose-related 
      drinking response. Chemical lesion produced by i.c.v. injection of the 
      catecholaminergic neurotoxin, 6-hydroxydopamine (25 micrograms x 3), or the 
      selective noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine 
      (250 micrograms), promoted significant antagonization of the dipsogenic behavior 
      produced by AIII (40 or 80 pmol, i.c.v.). Under equimolar doses (3.25 or 6.50 
      nmol), the specific alpha 1-adrenoceptor blocker, prazosin, antagonized; the 
      specific alpha 2-adrenoceptor antagonist, yohimbine, enhanced; and the 
      nonselective alpha-adrenoceptor blocker, phentolamine, elicited minimal action, 
      on AIII (40 pmol)-induced drinking response. These results suggest that central 
      noradrenergic neurotransmission may participate actively in AIII-induced 
      dipsogenesis, in a process that may involve both alpha 1- and alpha 
      2-adrenoceptors.
FAU - Chan, J Y
AU  - Chan JY
AD  - Department of Medical Research, Taipei Veterans General Hospital, Taiwan, 
      Republic of China.
FAU - Pan, S
AU  - Pan S
FAU - Chan, S H
AU  - Chan SH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Benzylamines)
RN  - 0 (Hydroxydopamines)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 0 (Sympathomimetics)
RN  - 11128-99-7 (Angiotensin II)
RN  - 2Y49VWD90Q (Yohimbine)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - 8Y164V895Y (Carbachol)
RN  - PQ1P7JP5C1 (DSP 4)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - XM03YJ541D (Prazosin)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Adrenergic alpha-Antagonists/pharmacology
MH  - Angiotensin II/administration & dosage/*pharmacology
MH  - Animals
MH  - Benzylamines/pharmacology
MH  - Carbachol/administration & dosage/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drinking Behavior/*drug effects
MH  - Drug Interactions
MH  - Hydroxydopamines/*pharmacology
MH  - Injections, Intravenous
MH  - Male
MH  - Norepinephrine/pharmacology/*physiology
MH  - Oxidopamine
MH  - Phentolamine/administration & dosage/pharmacology
MH  - Prazosin/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Adrenergic, alpha/classification/physiology
MH  - Sympathomimetics/pharmacology
MH  - Synaptic Transmission/*drug effects/physiology
MH  - Yohimbine/administration & dosage/pharmacology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0024-3205(91)90525-G [pii]
AID - 10.1016/0024-3205(91)90525-g [doi]
PST - ppublish
SO  - Life Sci. 1991;48(13):1293-301. doi: 10.1016/0024-3205(91)90525-g.