PMID- 16722325 OWN - NLM STAT- MEDLINE DCOM- 20060717 LR - 20161020 IS - 1088-5412 (Print) IS - 1088-5412 (Linking) VI - 27 IP - 2 Suppl 1 DP - 2006 Mar-Apr TI - The discovery of immunoglobulin E. PG - S3-6 AB - As early as 1919, from a case of transient asthma caused by blood transfusion, the presence in serum of a factor causing allergy was proposed. Despite intense search, this factor was not identified until 1968, when immunoglobulin E (IgE) was officially recognized by the World Health Organization. The knowledge about IgE mediating allergy has greatly improved our understanding of allergic inflammation and diagnoses and treatment of allergic diseases. FAU - Johansson, S G O AU - Johansson SG AD - Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden. s.g.o.johansson@ki.se LA - eng PT - Comparative Study PT - Journal Article PT - Review PL - United States TA - Allergy Asthma Proc JT - Allergy and asthma proceedings JID - 9603640 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Asthma/immunology/physiopathology MH - Humans MH - Hypersensitivity/immunology/physiopathology MH - Hypersensitivity, Immediate/*immunology MH - Immunization MH - Immunoglobulin E/*immunology MH - Sensitivity and Specificity RF - 24 EDAT- 2006/05/26 09:00 MHDA- 2006/07/18 09:00 CRDT- 2006/05/26 09:00 PHST- 2006/05/26 09:00 [pubmed] PHST- 2006/07/18 09:00 [medline] PHST- 2006/05/26 09:00 [entrez] PST - ppublish SO - Allergy Asthma Proc. 2006 Mar-Apr;27(2 Suppl 1):S3-6.