PMID- 16723796
OWN - NLM
STAT- MEDLINE
DCOM- 20060707
LR  - 20190819
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 70
IP  - 6
DP  - 2006 Jun
TI  - Effect of obstructive sleep apnea on aortic elastic parameters: relationship to 
      left ventricular mass and function.
PG  - 737-43
AB  - BACKGROUND: Obstructive sleep apnea (OSA) syndrome has a critical association 
      with cardiovascular mortality and morbidity. Aortic elastic parameters are 
      important markers for left ventricular (LV) function and are deteriorated in 
      cardiovascular disease. METHODS AND RESULTS: Aortic elastic parameters and LV 
      functions and mass were investigated in 40 patients with OSA (apnea - hypopnea 
      index (AHI) >or=5) (mean age 51.3 +/-9 years, 32 males) and 24 controls (AHI <5) 
      (mean age 51.9+/-5.2 years, 19 males). All subjects underwent polysomnographic 
      examination and recordings were obtained during sleep. They also underwent a 
      complete echocardiographic examination and systolic and diastolic aortic 
      measurements were noted from M-mode traces of the aortic root. There were no 
      significant differences in the demographic data of the patients with OSA and the 
      controls. Subjects with OSA demonstrated higher values of aortic stiffness 
      (7.1+/-1.88 vs 6.42+/-1.56, p=0.0001), but lower distensibility (9.47+/-1.33 vs 
      11.8+/-3.36, p=0.0001) than the controls. LV ejection fraction was significantly 
      lower in patients with OSA when compared with the control group (61.3+/-5.2% vs 
      65.9+/-8.4%, p=0.0001). LV diastolic parameters were also compared and were worse 
      in the subjects with OSA than in the control subjects (mitral E/A: 0.91 +/-0.42 
      vs 1.35+/-0.66, p=0.001; Em/Am: 0.86+/-0.54 vs 1.23+/-0.59, p=0.021). Respiratory 
      disturbance index had a positive correlation with aortic stiffness (r=0.63, 
      p=0.0001 and negative correlation with distensibility (r=-0.41, p=0.001). 
      CONCLUSION: Aortic elastic parameters are deteriorated in OSA, which has an 
      extremely high association with cardiovascular disease. Increased aortic 
      stiffness might be responsible for the LV systolic and diastolic deterioration in 
      OSA syndrome.
FAU - Tanriverdi, Halil
AU  - Tanriverdi H
AD  - Department of Cardiology, Pamukkale University School of Medicine, Denizli, 
      Turkey. drhaliltanriverdi@yahoo.com.tr
FAU - Evrengul, Harun
AU  - Evrengul H
FAU - Kaftan, Asuman
AU  - Kaftan A
FAU - Kara, Cuneyt Orhan
AU  - Kara CO
FAU - Kuru, Omur
AU  - Kuru O
FAU - Tanriverdi, Seyhan
AU  - Tanriverdi S
FAU - Ozkurt, Sibel
AU  - Ozkurt S
FAU - Semiz, Ender
AU  - Semiz E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Retracted Publication
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
RIN - Shimokawa H. Circ J. 2010 Sep;74(9):2026. PMID: 20689222
MH  - Adult
MH  - Aorta/diagnostic imaging/physiopathology
MH  - Echocardiography, Doppler
MH  - Elasticity
MH  - Female
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sleep Apnea, Obstructive/complications/diagnostic imaging/*physiopathology
MH  - Snoring/complications/diagnostic imaging/physiopathology
MH  - *Ventricular Function, Left
EDAT- 2006/05/26 09:00
MHDA- 2006/07/11 09:00
CRDT- 2006/05/26 09:00
PHST- 2006/05/26 09:00 [pubmed]
PHST- 2006/07/11 09:00 [medline]
PHST- 2006/05/26 09:00 [entrez]
AID - JST.JSTAGE/circj/70.737 [pii]
AID - 10.1253/circj.70.737 [doi]
PST - ppublish
SO  - Circ J. 2006 Jun;70(6):737-43. doi: 10.1253/circj.70.737.