PMID- 16724628
OWN - NLM
STAT- MEDLINE
DCOM- 20060801
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 27
IP  - 2
DP  - 2006 Mar-Apr
TI  - Adenosine deaminase polymorphism and the relationship of total immunoglobulin E 
      with skin prick test: a study on school children.
PG  - 115-8
AB  - Recent studies suggest that genetic polymorphism modulates immunoglobulin E 
      (IgE)-mediated atopic reactions. Adenosine is an important local hormone 
      influencing immune function and tissue reactivity; because adenosine 
      concentration is regulated by adenosine deaminase (ADA), we have investigated the 
      possible effect of ADA polymorphism on the relationship between IgE and positive 
      prick test. A random sample of 160 schoolchildren from the population of Viterbo 
      (Italy) were studied. Prick testing was performed with a panel of local 
      allergens. Total IgE assay was performed according to standard clinical 
      procedure. ADA phenotype was determined according to Spencer et al. A highly 
      significant correlation between prick test and IgE was observed. However, the 
      strength of correlation was moderate (eta2 = 0.16), indicating that positive 
      prick testing depends on other variables besides IgE. The relationship between 
      IgE and positive prick testing is stronger in carriers of ADA*2 allele than in 
      ADA*1/*1 subjects. Also, sensitivity and predictive values are higher in ADA*2 
      carriers than in homozygous ADA*1/*1 children. The data suggest that the effect 
      of IgE level on local reactivity is influenced by ADA polymorphism; at low level 
      of IgE, the presence of the ADA*2 allele seems to protect from positive prick 
      testing.
FAU - Gloria-Bottini, Fulvio
AU  - Gloria-Bottini F
AD  - Department of Biopathology and Imaging Diagnostics, University of Rome Tor 
      Vergata, Italy. gloria@med.uniroma2.it
FAU - Ronchetti, Francesco
AU  - Ronchetti F
FAU - Ammendola, Leonardo
AU  - Ammendola L
FAU - Bottini, Nunzio
AU  - Bottini N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.5.4.4 (Adenosine Deaminase)
SB  - IM
MH  - Adenosine Deaminase/*genetics
MH  - Asthma/blood/genetics
MH  - Child
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*blood/diagnosis/*genetics
MH  - Immunoglobulin E/*blood
MH  - Italy
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Skin Tests
EDAT- 2006/05/27 09:00
MHDA- 2006/08/02 09:00
CRDT- 2006/05/27 09:00
PHST- 2006/05/27 09:00 [pubmed]
PHST- 2006/08/02 09:00 [medline]
PHST- 2006/05/27 09:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2006 Mar-Apr;27(2):115-8.