PMID- 16724636
OWN - NLM
STAT- MEDLINE
DCOM- 20060801
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 27
IP  - 2
DP  - 2006 Mar-Apr
TI  - Efficacy, safety, and modulation of immunologic markers by immunotherapy with 
      honeybee venom: comparison of standardized quality depot versus aqueous extract.
PG  - 151-8
AB  - Venom immunotherapy (IT) is a very effective method for the treatment of 
      Hymenoptera venom allergy. We compared safety, efficacy, and modulation of 
      specific immunologic parameters in 70 patients sensitized to Apis mellifera, 
      treated for > or = 5 years with standardized quality (SQ) aqueous IT, either with 
      a rush (n = 20) or with a cluster (n = 20) induction protocol, or with an SQ 
      depot extract and a cluster induction protocol (n = 30). We made an open, 
      noncontrolled study. Side effects were monitored and the effects of field stings 
      during the maintenance phase of the treatment and after its interruption were 
      recorded. Skin reactivity to Apis was measured by end point dilution and specific 
      serum immunoglobulin E (IgE) were measured by a solid-phase-based assay. The 
      depot IT was better tolerated than aqueous IT with rush induction. This was 
      caused by mainly the lower frequency in the induction phase of systemic side 
      effects (3.4% versus 36.8% [p < 0.0041] on a "per patient" and 0.1% versus 0.9% 
      [p = 0.0092] on a "per dose "basis, respectively). The cluster protocol with the 
      aqueous extract tended to be better tolerated that the rush protocol. About 
      one-half of patients from each group were re-stung during the study and all 
      suffered only minor discomfort. Reduction of skin reactivity and of 
      serum-specific IgE was significant in the three groups (p < 0.02 in all cases). 
      SQ Depot IT to Apis venom allergy administered with a cluster protocol induces 
      less side effects and is equally effective then IT with SQ aqueous extract 
      administered with a rush protocol.
FAU - Quercia, Oliviero
AU  - Quercia O
AD  - Ambulatorio Allergologico, Ospedale di Faenza (RA), Italy.
FAU - Emiliani, Francesca
AU  - Emiliani F
FAU - Pecora, Silvia
AU  - Pecora S
FAU - Burastero, Samuele E
AU  - Burastero SE
FAU - Stefanini, Giuseppe F
AU  - Stefanini GF
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Bee Venoms)
RN  - 0 (Biomarkers)
RN  - 0 (Dosage Forms)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bee Venoms/*administration & dosage
MH  - Biomarkers/blood
MH  - Child
MH  - Desensitization, Immunologic/*methods
MH  - Dosage Forms
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/*therapy
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Skin Tests
MH  - Treatment Outcome
EDAT- 2006/05/27 09:00
MHDA- 2006/08/02 09:00
CRDT- 2006/05/27 09:00
PHST- 2006/05/27 09:00 [pubmed]
PHST- 2006/08/02 09:00 [medline]
PHST- 2006/05/27 09:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2006 Mar-Apr;27(2):151-8.