PMID- 16725043
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070806
LR  - 20181113
IS  - 1475-2859 (Electronic)
IS  - 1475-2859 (Linking)
VI  - 5
DP  - 2006 May 25
TI  - Miniature bioreactors: current practices and future opportunities.
PG  - 21
AB  - This review focuses on the emerging field of miniature bioreactors (MBRs), and 
      examines the way in which they are used to speed up many areas of bioprocessing. 
      MBRs aim to achieve this acceleration as a result of their inherent 
      high-throughput capability, which results from their ability to perform many cell 
      cultivations in parallel. There are several applications for MBRs, ranging from 
      media development and strain improvement to process optimisation. The potential 
      of MBRs for use in these applications will be explained in detail in this review. 
      MBRs are currently based on several existing bioreactor platforms such as shaken 
      devices, stirred-tank reactors and bubble columns. This review will present the 
      advantages and disadvantages of each design together with an appraisal of 
      prototype and commercialised devices developed for parallel operation. Finally we 
      will discuss how MBRs can be used in conjunction with automated robotic systems 
      and other miniature process units to deliver a fully-integrated, high-throughput 
      (HT) solution for cell cultivation process development.
FAU - Betts, Jonathan I
AU  - Betts JI
AD  - The Advanced Centre for Biochemical Engineering, Department of Biochemical 
      Engineering, University College London, Torrington Place, London, WC1E 7JE, UK. 
      jonathan.betts@genzyme.com
FAU - Baganz, Frank
AU  - Baganz F
LA  - eng
PT  - Journal Article
DEP - 20060525
PL  - England
TA  - Microb Cell Fact
JT  - Microbial cell factories
JID - 101139812
PMC - PMC1523360
EDAT- 2006/05/27 09:00
MHDA- 2006/05/27 09:01
PMCR- 2006/05/25
CRDT- 2006/05/27 09:00
PHST- 2006/02/18 00:00 [received]
PHST- 2006/05/25 00:00 [accepted]
PHST- 2006/05/27 09:00 [pubmed]
PHST- 2006/05/27 09:01 [medline]
PHST- 2006/05/27 09:00 [entrez]
PHST- 2006/05/25 00:00 [pmc-release]
AID - 1475-2859-5-21 [pii]
AID - 10.1186/1475-2859-5-21 [doi]
PST - epublish
SO  - Microb Cell Fact. 2006 May 25;5:21. doi: 10.1186/1475-2859-5-21.