PMID- 1672620
OWN - NLM
STAT- MEDLINE
DCOM- 19910506
LR  - 20190815
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 52
IP  - 1
DP  - 1991 Mar
TI  - Chromosome abnormalities in lymphocytes and fibroblasts of subjects with multiple 
      endocrine neoplasia type 1.
PG  - 85-92
AB  - A consistent degree of chromosome instability was found in cultured lymphocytes 
      and in fibroblasts derived from skin biopsies of three patients with multiple 
      endocrine neoplasia type 1 (MEN1). In both tissues, there was a significant 
      increase in chromosomal breakage. Dicentrics and tricentrics, rings, 
      translocations, deletions, acentric fragments, and presumptive double minutes 
      were the most frequent abnormalities in lymphocytes. The fibroblasts of two 
      patients had large clones consisting of trisomy 7 and trisomy 18 cells, 
      respectively.
FAU - Scappaticci, S
AU  - Scappaticci S
AD  - Biologia Generale e Genetica Medica, Universita di Pavia, Italy.
FAU - Maraschio, P
AU  - Maraschio P
FAU - del Ciotto, N
AU  - del Ciotto N
FAU - Fossati, G S
AU  - Fossati GS
FAU - Zonta, A
AU  - Zonta A
FAU - Fraccaro, M
AU  - Fraccaro M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Disorders
MH  - Chromosome Fragility
MH  - Female
MH  - Fibroblasts/*ultrastructure
MH  - Humans
MH  - Karyotyping
MH  - Lymphocytes/*ultrastructure
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/*genetics
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 0165-4608(91)90057-2 [pii]
AID - 10.1016/0165-4608(91)90057-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1991 Mar;52(1):85-92. doi: 10.1016/0165-4608(91)90057-2.