PMID- 16728260
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20060526
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 6
DP  - 2006 Jun
TI  - Why cord blood?
PG  - 398-404
AB  - Cord blood, donated by mothers after the birth of their children, has become an 
      accepted source of related and unrelated hematopoietic stem cells for marrow 
      reconstitution. We estimate that some 7-8000 unrelated-donor cord blood 
      transplants have been performed worldwide since 1993. The development of cord 
      blood as a source of hematopoietic stem cells for transplantation started with 
      the early recognition of the presence in cord blood of colony-forming cells by 
      Knudtzon in 1974. The first cord blood transplant from a human leukocyte antigen 
      (HLA)-identical sib to a young patient with Fanconi anemia was performed by 
      Gluckman in 1988 and opened the way for the subsequent development of a bank for 
      donations for unrelated patients by our group at the New York Blood Center. It is 
      now widely recognized that two transplant-dependent variables exert strong 
      influence on the chance for long-term recipient survival: the hematopoietic stem 
      and progenitor cell dose and the HLA match grade. Hence, despite the generally 
      milder graft-vs-host disease after mismatched cord blood transplantation, large 
      and ethnically diverse inventories of cord blood are needed to permit better HLA 
      matches and long-term survivals. In this review, a number of issues that are 
      relevant to the history and development of an effective system for cord blood 
      banking are discussed.
FAU - Rubinstein, Pablo
AU  - Rubinstein P
AD  - National Cord Blood Program, Milstein Cord Blood Center, New York Blood Center, 
      NY, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060330
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Blood Banks
MH  - Bone Marrow Transplantation
MH  - *Cord Blood Stem Cell Transplantation
MH  - Donor Selection
MH  - *Fetal Blood
MH  - HLA Antigens/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility
MH  - Humans
RF  - 33
EDAT- 2006/05/27 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/05/27 09:00
PHST- 2006/02/21 00:00 [received]
PHST- 2006/05/27 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/05/27 09:00 [entrez]
AID - S0198-8859(06)00055-3 [pii]
AID - 10.1016/j.humimm.2006.03.015 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Jun;67(6):398-404. doi: 10.1016/j.humimm.2006.03.015. Epub 2006 
      Mar 30.