PMID- 16728264
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20060526
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 6
DP  - 2006 Jun
TI  - Differential immunogenicity of HLA class I alloantigens for the humoral versus 
      the cellular immune response: "towards tailor-made HLA mismatching".
PG  - 424-9
AB  - The immunogenicity of an individual human leukocyte antigen (HLA) class I 
      mismatch is different for the cellular and the humoral alloimmune responses. The 
      consequence is that the same antigen can induce a strong antibody response and no 
      cytotoxic T lymphocyte reactivity, but the reverse can occur also. Exact 
      knowledge of the immunogenicity of an HLA mismatch for an individual patient can 
      lead to a strategy of tailor-made HLA mismatching if no HLA identical donor is 
      available. Depending on the clinical situation, one should select a donor with 
      HLA mismatches according to the humoral or cellular mismatch algorithm.
FAU - Claas, Frans H J
AU  - Claas FH
AD  - Department of Immunohematology and Blood Transfusion, Leiden University Medical 
      Center, the Netherlands. fbjclaas@lumc.nl
FAU - Roelen, Dave L
AU  - Roelen DL
FAU - Mulder, Arend
AU  - Mulder A
FAU - Doxiadis, Ilias I N
AU  - Doxiadis II
FAU - Oudshoorn, Machteld
AU  - Oudshoorn M
FAU - Heemskerk, Martin
AU  - Heemskerk M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060330
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Isoantigens)
SB  - IM
MH  - *Antibody Formation
MH  - *Donor Selection
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Immunity, Cellular
MH  - Isoantigens/*immunology
RF  - 35
EDAT- 2006/05/27 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/05/27 09:00
PHST- 2006/02/21 00:00 [received]
PHST- 2006/05/27 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/05/27 09:00 [entrez]
AID - S0198-8859(06)00043-7 [pii]
AID - 10.1016/j.humimm.2006.03.004 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Jun;67(6):424-9. doi: 10.1016/j.humimm.2006.03.004. Epub 2006 
      Mar 30.