PMID- 16728266
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20060526
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 6
DP  - 2006 Jun
TI  - Minor histocompatibility antigens: from transplantation problems to therapy of 
      cancer.
PG  - 433-8
AB  - The idea of transferring healthy marrow for the therapeutic treatment of the 
      various diseases of the blood and of the immune system made a significant 
      contribution to controlling diseases and to advancing modern clinical sciences. 
      The first series of bone marrow transplantations in the 1960s were confronted 
      with severe complications. It became clear that matching for the human leukocyte 
      antigen (HLA) system between donor and recipient significantly improved the 
      clinical results. Nonetheless, an unacceptable percentage of severe complications 
      remained that is mainly attributable to non-HLA histocompatibility systems, i.e., 
      minor histocompatibility antigens. Observations in the 1970s that minor 
      histocompatibility antigens cause serious problems in human bone marrow 
      transplantation laid the basis for their use as curative antigens in stem cell 
      transplantation to date. Thus, the allo-immune T cell activities caused by minor 
      histocompatibililty antigen disparities between HLA-matched donor and recipient 
      can now be applied for the benefit of the transplant patient.
FAU - Goulmy, Els
AU  - Goulmy E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060406
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Cancer Vaccines)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Bone Marrow Transplantation/*immunology
MH  - Cancer Vaccines/immunology/*therapeutic use
MH  - Female
MH  - Fetal Blood/immunology
MH  - Graft Rejection/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Maternal-Fetal Exchange/immunology
MH  - Minor Histocompatibility Antigens/*immunology
MH  - Neoplasms/immunology/therapy
MH  - Peptide Fragments/immunology
MH  - Pregnancy
RF  - 49
EDAT- 2006/05/27 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/05/27 09:00
PHST- 2006/02/21 00:00 [received]
PHST- 2006/05/27 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/05/27 09:00 [entrez]
AID - S0198-8859(06)00052-8 [pii]
AID - 10.1016/j.humimm.2006.03.012 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Jun;67(6):433-8. doi: 10.1016/j.humimm.2006.03.012. Epub 2006 
      Apr 6.